Artículo
Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz
; Olmedo, Daniel Gustavo
Fecha de publicación:
06/2017
Editorial:
SAGE Publications
Revista:
Toxicologic Pathology
ISSN:
0192-6233
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
As a result of biotribocorrosion, the surface of a titanium (Ti) biomedical device can be a potential source of systemic contamination with Ti nanoparticles (NPs). Although NPs can be chemically similar, differences in particle size may lead to different biological responses. The aim of this experimental study was to determine Ti trace levels in skin appendages and plasma and explore the influence of NP size on trace levels using a murine model. Results showed the presence of Ti traces in the nails, hair, and plasma. The concentration of the smallest NPs (5 Nm) was higher than that of 10 Nm NPs in all the studied samples. Irrespective of NP size, Ti levels were always lower in plasma than in skin appendages. Ti levels were higher in nails than in hair. Ti NPs size influenced trace concentration levels in hair/nails, suggesting that 5 Nm Ti particles are more easily eliminated through these skin appendages. Given that the nails showed the highest levels of Ti, and that these skin appendages are not exposed to agents that can leach out Ti, as occurs with hair, we propose the nails as the most suitable and reliable bioindicator for monitoring systemic contamination with Ti.
Palabras clave:
Biomarker
,
Hair
,
Nails
,
Nanoparticles
,
Skin Appendages
,
Titanium
,
Tribocorrosion
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo; Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages; SAGE Publications; Toxicologic Pathology; 45; 5; 6-2017; 624-632
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