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Artículo

White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies

Pagano, Eleonora SamantaIcon ; Spinedi, Eduardo JulioIcon ; Gagliardino, Juan JoseIcon
Fecha de publicación: 04/2017
Editorial: Karger
Revista: Neuroendocrinology
ISSN: 0028-3835
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
Palabras clave: ADIPOSE TISSUE DYSFUNCTION , ADIPOSE TISSUE MASS EXPANSION , CENTRAL/PERIPHERAL CLOCKS , CHRONOBIOLOGY , CHRONOTHERAPEUTIC APPROACH , CLOCK GENES , FEEDING TIME , GLUCOSE REGULATION , NUTRIENTS , OBESITY PATHOGENESIS , OBESITY PREVENTION/TREATMENT
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47725
DOI: https://dx.doi.org/10.1159/000453317
URL: https://www.karger.com/Article/FullText/453317
Colecciones
Articulos(CENEXA)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Pagano, Eleonora Samanta; Spinedi, Eduardo Julio; Gagliardino, Juan Jose; White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies; Karger; Neuroendocrinology; 104; 4; 4-2017; 347-363
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