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dc.contributor.author
Di Gregorio, Sabrina Noelia
dc.contributor.author
Fernandez, Silvina
dc.contributor.author
Cuirolo, Arabela Ximena
dc.contributor.author
Verlaine, Olivier
dc.contributor.author
Amoroso, Ana
dc.contributor.author
Mengin Lecreulx, Dominique
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Famiglietti, Angela María Rosa
dc.contributor.author
Joris, Bernard
dc.contributor.author
Mollerach, Marta Eugenia
dc.date.available
2018-06-07T18:29:28Z
dc.date.issued
2017-01
dc.identifier.citation
Di Gregorio, Sabrina Noelia; Fernandez, Silvina; Cuirolo, Arabela Ximena; Verlaine, Olivier; Amoroso, Ana; et al.; Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 23; 1; 1-2017; 44-50
dc.identifier.issn
1076-6294
dc.identifier.uri
http://hdl.handle.net/11336/47723
dc.description.abstract
The aim of this study is to characterize the factors related to peptidoglycan metabolism in isogenic hVISA/VISA ST100 strains. Recently, we reported the increase in IS256 transposition in invasive hVISA ST100 clinical strains isolated from the same patient (D1 and D2) before and after vancomycin treatment and two laboratory VISA mutants (D23C9 and D2P11) selected from D2 in independent experiments. High performance liquid chromatography-mass spectrometry (HPLC-MS) analysis of peptidoglycan muropeptides showed increased proportion of monomeric muropeptides and a concomitant decrease in the proportion of tetrameric muropeptide in D2 and derived mutants when compared to the original strain D1. In addition, strain D2 and its derived mutants showed an increase in cell wall thickness with increased pbp2 gene expression. The VISA phenotype was not stable in D2P11 and showed a reduced autolysis profile. On the other hand, the mutant D23C9 differentiates from D2 and D2P11 in the autolysis profile, and pbp4 transcription profile. D2-derived mutants exhibited differences in the susceptibility to other antimicrobials. Our results highlight the possibility of selection of different VISA phenotypes from a single hVISA-ST100 genetic background.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Staphylococcus Aureus
dc.subject
Vancomycin
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Hvisa
dc.subject
Vis
dc.subject
Mrsa St100
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T14:25:04Z
dc.journal.volume
23
dc.journal.number
1
dc.journal.pagination
44-50
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fernandez, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
dc.description.fil
Fil: Cuirolo, Arabela Ximena. Université de Liège; Bélgica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Verlaine, Olivier. Université de Liège; Bélgica
dc.description.fil
Fil: Amoroso, Ana. Université de Liège; Bélgica
dc.description.fil
Fil: Mengin Lecreulx, Dominique. Université Paris Sud; Francia
dc.description.fil
Fil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Joris, Bernard. Université de Liège; Bélgica
dc.description.fil
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Microbial Drug Resistance: Mechanisms Epidemiology and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1089/mdr.2016.0160
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2016.0160


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