Artículo
NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition
Fecha de publicación:
07/2017
Editorial:
Hindawi Publishing Corporation
Revista:
Neural Plasticity
ISSN:
2090-5904
e-ISSN:
1687-5443
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory. NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile. In CNS structures involved in cognitive functions as the hippocampus and prefrontal cortex, GluN2A and GluN2B are major regulatory subunits; their expression is dynamic and tightly regulated, but little is known about specific changes after plasticity induction or memory acquisition. Data strongly suggest that following appropriate stimulation, there is a rapid increase in surface GluN2A-NMDAR at the postsynapses, attributed to lateral receptor mobilization from adjacent locations. Whenever synaptic plasticity is induced or memory is consolidated, more GluN2A-NMDARs are assembled likely using GluN2A from a local translation and GluN1 from local ER. Later on, NMDARs are mobilized from other pools, and there are de novo syntheses at the neuron soma. Changes in GluN1 or NMDAR levels induced by synaptic plasticity and by spatial memory formation seem to occur in different waves of NMDAR transport/expression/degradation, with a net increase at the postsynaptic side and a rise in expression at both the spine and neuronal soma. This review aims to put together that information and the proposed hypotheses.
Palabras clave:
Glun2a-Nmdar
,
Synaptic Plasticity
,
Memory Acquisition
,
Protein Expression
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Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Baez, Maria Veronica; Cercato, Magalí Cecilia; Jerusalinsky, Diana Alicia; NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition; Hindawi Publishing Corporation; Neural Plasticity; 2018; 7-2017; 1-11; 5093048
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