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dc.contributor.author
Phelan, Kevin D.
dc.contributor.author
Shwe, U Thaung
dc.contributor.author
Cozart, Michael A.
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Wu, Hong
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Mock, Matthew M.
dc.contributor.author
Abramowitz, Joel
dc.contributor.author
Birnbaumer, Lutz
dc.contributor.author
Zheng, Fang
dc.date.available
2018-06-07T17:56:47Z
dc.date.issued
2017-02
dc.identifier.citation
Phelan, Kevin D.; Shwe, U Thaung; Cozart, Michael A.; Wu, Hong; Mock, Matthew M.; et al.; TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice; Wiley Blackwell Publishing, Inc; Epilepsia; 58; 2; 2-2017; 247-254
dc.identifier.issn
0013-9580
dc.identifier.uri
http://hdl.handle.net/11336/47700
dc.description.abstract
Objective: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE). Methods: The role of TRPC3 channels was investigated using TRPC3 knockout (KO) mice and TRPC3-selective inhibitor Pyr3. Video and electroencephalography (EEG) recording of pilocarpine-induced seizures were performed. Results: We found that genetic ablation of TRPC3 channels reduces behavioral manifestations of seizures and the root-mean-square (RMS) power of SE, indicating a significant contribution of TRPC3 channels to pilocarpine-induced SE. Furthermore, the reduction in SE in TRPC3KO mice is caused by a selective attenuation of pilocarpine-induced theta activity, which dominates both the preictal phase and SE phase. Pyr3 also caused a reduction in the overall RMS power of pilocarpine-induced SE and a selective reduction in the theta activity during SE. Significance: Our results demonstrate that TRPC3 channels unequivocally contribute to pilocarpine-induced SE and could be a novel molecular target for new anticonvulsive drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Beta Rhythm
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Electroencephalography
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Gamma Rhythm
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Seizures
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Spectral Analysis
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Transient Receptor Potential Channels
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T14:08:51Z
dc.journal.volume
58
dc.journal.number
2
dc.journal.pagination
247-254
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Phelan, Kevin D.. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Shwe, U Thaung. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Cozart, Michael A.. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Wu, Hong. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Mock, Matthew M.. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados Unidos
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institute of Environmental Health Sciences; Estados Unidos. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Zheng, Fang. University of Arkansas for Medical Sciences; Estados Unidos
dc.journal.title
Epilepsia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/epi.13648
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.13648
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