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Artículo

The Immune System As a New Possible Cell Target for AFP 464 in a Spontaneous Mammary Cancer Mouse Model

Callero, Mariana AlejandraIcon ; Rodríguez, Cristina ElisaIcon ; Sólimo, Aldana; Bal, Elisa DoraIcon ; Loaiza Perez, Andrea IreneIcon
Fecha de publicación: 09/2017
Editorial: Wiley-liss, Div John Wiley & Sons Inc
Revista: Journal of Cellular Biochemistry
ISSN: 0730-2312
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

Aminoflavone (AFP 464, NSC 710464), an antitumor agent which recently entered phase II clinical trials, acts against estrogen-positive breast cancer (ER +). AFP 464, which has a unique mechanism of action by activating aryl hydrocarbon receptor (AhR) signaling pathway, decreased tumor size and growth rate in the estrogen dependent, Tamoxifen-sensitive spontaneous M05 mouse model. Considering that AhR has recently emerged as a physiological regulator of the innate and adaptive immune responses, we investigated whether AFP 464 modulates the immune response in our mouse model. Studies on the effect of AFP 464 on the immune system were carried in BALB/c mice bearing M05 semi-differentiated mammary adenocarcinomas that express estrogen and progesterone receptors. Splenic cells and tumor inflammatory infiltrates were studied by cytometric analyses. The modulation of splenocytes cytotoxic activity by AFP 464 was also evaluated. We further investigated the effects of AFP 464 on peritoneal macrophages by evaluating metalloproteinase, arginase and iNOS activities. We found that AFP 464 increased splenic cytotoxic activity, diminished the number of systemic and local Treg lymphocytes and MDSCs, and induced a M1 phenotype in peritoneal macrophages of M05 tumor bearing mice. Therefore, we conclude that AFP 464 modulates immune response which collaborates with its anti-tumor activity. Our results place the immune system as a novel target for this anti-cancer agent to strengthen the rationale for its inclusion in breast cancer treatment regimens.
Palabras clave: Mammary Carcinoma , Immune System , Afp 464 , Ahr
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47698
DOI: https://dx.doi.org/10.1002/jcb.25934
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.25934
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Callero, Mariana Alejandra; Rodríguez, Cristina Elisa; Sólimo, Aldana; Bal, Elisa Dora; Loaiza Perez, Andrea Irene; The Immune System As a New Possible Cell Target for AFP 464 in a Spontaneous Mammary Cancer Mouse Model; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Biochemistry; 118; 9; 9-2017; 2841-2849
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