Artículo
Effects of 2-iodohexadecanal in the physiology of thyroid cells
Rossich, Luciano Esteban
; Thomasz, Lisa
; Nicola, Juan Pablo
; Nazar, Magalí
; Salvarredi, Leonardo Andres
; Pisarev, Mario Alberto
; Masini Repiso, Ana María; Christophe Hobertus, Christiane; Christophe, Daniel; Juvenal, Guillermo Juan
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Fecha de publicación:
05/12/2016
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them, 2-iodohexadecanal (2-IHDA) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and 2-IHDA on thyroid cell physiology. For this purpose, FRTL-5 thyroid cells were incubated with the two compounds during 24 or 48 h and several thyroid parameters were evaluated such as: iodide uptake, intracellular calcium and H<sub>2</sub>O<sub>2</sub> levels. To further explore the molecular mechanism involved in 2-IHDA action, transcript and protein levels of genes involved in thyroid hormone biosynthesis, as well as the transcriptional expression of these genes were evaluated in the presence of iodide and 2-IHDA. The results obtained indicate that 2-IHDA reproduces the action of excess iodide on the "Wolff-Chaikoff" effect as well as on thyroid specific genes transcription supporting its role in thyroid autoregulation.
Palabras clave:
Thyroid
,
2-Iodohexadecanal
,
Wolff-Chaikoff Effect
,
Iodide Excess
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Rossich, Luciano Esteban; Thomasz, Lisa; Nicola, Juan Pablo; Nazar, Magalí; Salvarredi, Leonardo Andres; et al.; Effects of 2-iodohexadecanal in the physiology of thyroid cells; Elsevier Ireland; Molecular and Cellular Endocrinology; 437; 5-12-2016; 292-301
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