Artículo
Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy
Sarmiento Varon, Lindybeth
; De Rosa, Javier; Machicote, Andrés Pablo
; Billordo, Luis Ariel
; Baz, Placida
; Fernandez, Pablo Mariano
; Kaimen Maciel, Isabel; Blanco, Andrés; Arana, Eloisa
Fecha de publicación:
12/2017
Editorial:
Nature Publishing Group
Revista:
Scientific Reports
ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported. We immunophenotyped tonsillar IL10-expressing B cells (B10) and observed IL10 production in activated B cells at every developmental stage. Finally, we identified a relationship between decreased B10 percentages, increased proportion of the germinal centre (GC) population and hypertrophied tonsils (HT). Our findings provide greater insight into the role of B10 in GC reactions and characterized their involvement in the pathogenesis of tonsillar dysfunction.
Palabras clave:
Pathogenesis
,
Immunology
,
Tonsillar
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Identificadores
Colecciones
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Sarmiento Varon, Lindybeth; De Rosa, Javier; Machicote, Andrés Pablo; Billordo, Luis Ariel; Baz, Placida; et al.; Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017
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