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dc.contributor.author
Perez Ipiña, Emiliano
dc.contributor.author
Ponce Dawson, Silvina Martha
dc.date.available
2018-06-07T14:13:50Z
dc.date.issued
2016-03
dc.identifier.citation
Perez Ipiña, Emiliano; Ponce Dawson, Silvina Martha; Fluctuations, correlations and the estimation of concentrations inside cells; Public Library of Science; Plos One; 11; 3; 3-2016; 1-20
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/47648
dc.description.abstract
Information transmission in cells occurs quite accurately even when concentration changes are "read" by individual binding sites. In this paper we study ligand number and site occupancy fluctuations when ligands diffuse and react going beyond the analyses that focus on their asymptotic decay. In this way we show that, for immobile binding sites, fluctuations in the number of bound molecules decay on a relatively fast scale before the asymptotic behavior kicks in. This result can explain the observed co-existence of highly fluctuating instantaneous transcriptional activities with accumulated mRNA concentrations that have relatively small noise levels. We also show that the initial stages of the decay in the bound molecule number fluctuations have one or two characteristic timescales depending on the concentration of free molecules. This transition can explain the changes in enzyme activity observed at the single molecule level.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.relation
Corrección en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192091
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fluctuations
dc.subject
Information Transmission
dc.subject
Reaction-Diffusion
dc.subject
Cells
dc.subject.classification
Astronomía
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Fluctuations, correlations and the estimation of concentrations inside cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-01T13:55:37Z
dc.journal.volume
11
dc.journal.number
3
dc.journal.pagination
1-20
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Perez Ipiña, Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
dc.description.fil
Fil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0151132
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