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dc.contributor.author
Orsini, Sara
dc.contributor.author
Noris, Patrizia
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Bury, Loredana
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Heller, Paula Graciela
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Santoro, Cristina
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Kadir RA
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Butta, Nora C.
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Falcinelli, Emanuela
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Cid, Ana Rosa
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Fabris, Fabrizio
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Fouassier, Marc
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Miyazaki, Koji
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Lozano, Maria Luisa
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Zuñiga, Pamela
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Flaujac, Claire
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Podda, Gian Marco
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Bermejo, Nuria
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Favier, Remi
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Henskens, Yvonne
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De Maistre, Emmanuel
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De Candia, Erica
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Mumford, Andrew
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Ozdemir, Gul Nihal
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Eker, Ibrahim
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Nurden, Paquita
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Bayart, Sophie
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Lambert, Michele P
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Bussel, James
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Zieger, Barbara
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Tosseto, Alberto
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Melazzini, Federica
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Glembotsky, Ana Claudia
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Pecci, Alessandro
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Cattaneo, Marco
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Schlegel, Nicole
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Gresele, Paolo
dc.date.available
2018-06-06T20:05:04Z
dc.date.issued
2017-04
dc.identifier.citation
Orsini, Sara; Noris, Patrizia; Bury, Loredana; Heller, Paula Graciela; Santoro, Cristina; et al.; Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. The Surgery in Platelet disorders And Therapeutic Approach (SPATA) study; Ferrata Storti Foundation; Haematologica; 102; 4-2017; 1192-1203
dc.identifier.issn
0390-6078
dc.identifier.uri
http://hdl.handle.net/11336/47588
dc.description.abstract
Excessive bleeding at surgery is a feared complication in patients with inherited platelet disorders (IPD), however very few studies have evaluated the frequency of surgical bleeding in these hemorrhagic disorders. We performed a multicentric, retrospective worldwide study to assess the bleeding complications of surgery, the preventive and therapeutic approaches adopted and their efficacy in patients with IPDs by rating the outcome of 829 surgical procedures carried out in 423 patients with well defined forms of IPD (238 inherited platelet function disorders -IPFD- and 185 inherited platelet number disorders-IPND-). Frequency of surgical bleeding was high in patients with IPD (19.7%), with a significantly higher bleeding incidence in IPFDs (24.8%) than in IPNDs (13.4%). The frequency of bleeding varied according to the type of IPD, with biallelic Bernard Soulier syndrome having the highest occurrence (44.4%), and was predicted by a preoperative WHO bleeding score >/-2. Some types of surgery were associated with a higher bleeding incidence, like cardiovascular and urologic surgery. The use of preoperative prohemostatic treatments was associated with a lower bleeding frequency in patients with IPFD but not in IPNDs. Desmopressin, alone or with antifibrinolytic agents, was the preventive treatment associated with lowest bleedings. Platelet transfusions were used more frequently in patients at higher bleeding risk. Surgical bleeding risk in IPD is substantial, especially in IPFDs, and bleeding history, type of disorder, type of surgery and female gender are associated with higher bleeding frequency. Prophylactic preoperative prohemostatic treatments appear to be required and associated with a lower bleeding incidence.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Ferrata Storti Foundation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Platelets
dc.subject
Bleeding
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Inherited Thrombocytopenia
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Surgery
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. The Surgery in Platelet disorders And Therapeutic Approach (SPATA) study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-04T17:09:10Z
dc.identifier.eissn
1592-8721
dc.journal.volume
102
dc.journal.pagination
1192-1203
dc.journal.pais
Italia
dc.journal.ciudad
Pavia
dc.description.fil
Fil: Orsini, Sara. Università di Perugia; Italia
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Fil: Noris, Patrizia. University Of Pavia. Policlinico San Matteo; Italia
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Fil: Bury, Loredana. Università di Perugia; Italia
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Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
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Fil: Santoro, Cristina. Università degli studi di Roma ; Italia
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Fil: Kadir RA. Royal Free Hospital; Reino Unido
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Fil: Butta, Nora C.. Hospital Universitario la Paz; España
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Fil: Falcinelli, Emanuela. Università di Perugia; Italia
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Fil: Cid, Ana Rosa. Hospital Universitario y Politecnico ; España
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Fil: Fabris, Fabrizio. Università di Padova; Italia
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Fil: Fouassier, Marc. Centre Hospitalier Universitaire de Nantes; Francia
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Fil: Miyazaki, Koji. Kitasato University. School Of Medicine; Japón
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Fil: Lozano, Maria Luisa. Universidad Carlos III de Madrid. Instituto de Salud; España
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Fil: Zuñiga, Pamela. Pontificia Universidad Católica de Chile; Chile
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Fil: Flaujac, Claire. Cochin Hospital; Francia
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Fil: Podda, Gian Marco. Università degli Studi di Milano; Italia
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Fil: Bermejo, Nuria. Hospital ; España
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Fil: Favier, Remi. French Reference Centre For Inherited Platelet Disorder; Francia
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Fil: Henskens, Yvonne. Maastricht University. Medical Centre; Países Bajos
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Fil: De Maistre, Emmanuel. Centre Hospitalier Universitaire Dijon; Francia
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Fil: De Candia, Erica. Universitá Cattolica Sacro. Policlinico Agostino Gemelli; Italia
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Fil: Mumford, Andrew. University Of Bristol. School Of Clinical Sciences; Reino Unido
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Fil: Ozdemir, Gul Nihal. Cerrahpasa Medical Faculty. Pediatric Hematology Depart; Turquía
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Fil: Eker, Ibrahim. Gülhane Military Medical Faculty. Pediatric Hematology; Turquía
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Fil: Nurden, Paquita. Xavier Arnozan Hospital; Francia
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Fil: Bayart, Sophie. Centre Régional de Traitement Des Hémophiles; Francia
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Fil: Lambert, Michele P. University of Pennsylvania; Estados Unidos
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Fil: Bussel, James. Weill Cornell Medicine; Estados Unidos
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Fil: Zieger, Barbara. University Medical Center Freiburg; Alemania
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Fil: Tosseto, Alberto. San Bortolo Hospital; Italia
dc.description.fil
Fil: Melazzini, Federica. Università degli studi di Pavia. Policlinico San Matteo; Italia
dc.description.fil
Fil: Glembotsky, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Pecci, Alessandro. Università degli studi di Pavia. Policlinico San Matteo; Italia
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Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia
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Fil: Schlegel, Nicole. Centre Hospitalier Universitaire ; Francia
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Fil: Gresele, Paolo. Università di Perugia; Italia
dc.journal.title
Haematologica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/lookup/doi/10.3324/haematol.2016.160754
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3324/haematol.2016.160754


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