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dc.contributor.author
Perazzo, Priscila
dc.contributor.author
Eguibar, Nair
dc.contributor.author
Gonzalez, Rodrigo Horacio
dc.contributor.author
Nusblat, Alejandro David
dc.contributor.author
Cuestas, María Luján
dc.date.available
2018-06-06T19:18:00Z
dc.date.issued
2015-04
dc.identifier.citation
Perazzo, Priscila; Eguibar, Nair; Gonzalez, Rodrigo Horacio; Nusblat, Alejandro David; Cuestas, María Luján; Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now; MedCrave; Journal of Human Virology &Retrovirology; 2; 3; 4-2015; 46-55
dc.identifier.issn
2373-6453
dc.identifier.uri
http://hdl.handle.net/11336/47548
dc.description.abstract
Despite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection remains a major health care problem. More than 240 million people are chronically infected worldwide showing differences in the severity of liver disease, clinical outcome and response to immune- and antiviral-therapy. Parameters associated with the host immune system (HBV specific T- and/or B-cell repertoires, defective antigen presentation and diminished Th1/Th2 response ratio) and viral factors such as the HBV genotypes and their evolving variants/mutants, have largely contributed to explaining such differences. The unique genomic structure and replication cycle of HBV provide much opportunity for mutations to occur in any of its genes undergoing selection pressures, such as those associated with the host immune system, the hepatitis B vaccine and/or hepatitis B immune globulin and the antiviral therapy with nucleos(t)ide analogues. Firstly, this review describes the current prevalence of S-escape mutants worldwide. Secondly, the clinical implications of such surface gene variants and the impact of universal hepatitis B vaccination on HBV mutations and genotypes are discussed. Finally, the fact that the immune escape process also extends well beyond HBV is addressed.<br />
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MedCrave
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hbv
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Hbsag
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S-Immune
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Escape
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Mutants
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Hepatitis-B
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Vaccine
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Obi
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Hbig
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T18:43:46Z
dc.journal.volume
2
dc.journal.number
3
dc.journal.pagination
46-55
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Arizona
dc.description.fil
Fil: Perazzo, Priscila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Eguibar, Nair. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Gonzalez, Rodrigo Horacio. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Nusblat, Alejandro David. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Cuestas, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.journal.title
Journal of Human Virology &Retrovirology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.15406/jhvrv.2015.02.00046
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://medcraveonline.com/JHVRV/JHVRV-02-00046.php
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