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dc.contributor.author
Muscia, Gisela Celeste
dc.contributor.author
Asís, Silvia Elizabeth
dc.contributor.author
Buldain, Graciela Yolanda
dc.date.available
2018-06-06T18:58:35Z
dc.date.issued
2017-07
dc.identifier.citation
Muscia, Gisela Celeste; Asís, Silvia Elizabeth; Buldain, Graciela Yolanda; Microwave-assisted Synthesis of 2-Styrylquinoline-4-carboxylic Acids as Antitubercular Agents; Bentham Science Publishers; Medicinal Chemistry; 13; 5; 7-2017; 1-5
dc.identifier.issn
1573-4064
dc.identifier.uri
http://hdl.handle.net/11336/47528
dc.description.abstract
Background: Many 2-substituted quinolines and especially 2-arylvinyl derivatives isolated from plants or prepared by synthesis have been designed from ethnopharmacological studies. Objective: In order to explore new aspects of the structure-antituberculosis activity relationship, a series of styrylquinoline derivatives was prepared. Method: A series of styrylquinoline derivatives was prepared from quinaldic acid and a variety of arylbenzaldehydes under eco-friendly conditions via Knoevenagel reaction and trifluoroacetic acid (TFA) as catalyst. Results: The products were obtained in short reaction times and good yields and were evaluated for growth inhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute of Allergy and Infectious Diseases (NIAID, USA). Conclusion: Three compounds had activity under aerobic conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Synthesis
dc.subject
Microwave
dc.subject
Styrylquinolines
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Catalysis
dc.subject
Mycobacterium Tuberculosis
dc.subject
Tuberculosis
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Microwave-assisted Synthesis of 2-Styrylquinoline-4-carboxylic Acids as Antitubercular Agents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T13:37:42Z
dc.journal.volume
13
dc.journal.number
5
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oak Park
dc.description.fil
Fil: Muscia, Gisela Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Asís, Silvia Elizabeth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Buldain, Graciela Yolanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina
dc.journal.title
Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.2174/1573406412666160901102710
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/145223/article


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