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dc.contributor.author
Jones, Leandro Roberto  
dc.contributor.author
Sede, Mariano Miguel  
dc.contributor.author
Manrique, Julieta Marina  
dc.contributor.author
Quarleri, Jorge Fabian  
dc.date.available
2018-06-06T18:26:03Z  
dc.date.issued
2016-07  
dc.identifier.citation
Jones, Leandro Roberto; Sede, Mariano Miguel; Manrique, Julieta Marina; Quarleri, Jorge Fabian; Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing; Springer Wien; Archives of Virology; 161; 10; 7-2016; 2885-2891  
dc.identifier.issn
0304-8608  
dc.identifier.uri
http://hdl.handle.net/11336/47524  
dc.description.abstract
HBV phylogenetics and resistance-associated mutations (RAMs) were surveyed by next-generation sequencing of 21 longitudinal samples from seven patients entering antiviral therapy. The virus populations were dominated by a few abundant lineages that coexisted with substantial numbers of low-frequency variants. A few low-frequency RAMs were observed before treatment, but new ones emerged, and their frequencies increased during therapy. Together, these results support the idea that chronic HBV infection is dominated by a few virus lineages and that an accompanying plethora of diverse, low-frequency variants may function as a reservoir that potentially contribute to viral genetic plasticity, potentially affecting patient outcome.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer Wien  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Hbv  
dc.subject
Hiv  
dc.subject
Ngs  
dc.subject
Rams  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-05-29T21:12:07Z  
dc.identifier.eissn
1432-8798  
dc.journal.volume
161  
dc.journal.number
10  
dc.journal.pagination
2885-2891  
dc.journal.pais
Austria  
dc.journal.ciudad
Viena  
dc.description.fil
Fil: Jones, Leandro Roberto. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Trelew; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Sede, Mariano Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina  
dc.description.fil
Fil: Manrique, Julieta Marina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Trelew; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina  
dc.journal.title
Archives of Virology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00705-016-2959-8  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-016-2959-8