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dc.contributor.author Jones, Leandro Roberto
dc.contributor.author Sede, Mariano Miguel
dc.contributor.author Manrique, Julieta Marina
dc.contributor.author Quarleri, Jorge Fabian
dc.date.available 2018-06-06T18:26:03Z
dc.date.issued 2016-07
dc.identifier.citation Jones, Leandro Roberto; Sede, Mariano Miguel; Manrique, Julieta Marina; Quarleri, Jorge Fabian; Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing; Springer Wien; Archives of Virology; 161; 10; 7-2016; 2885-2891
dc.identifier.issn 0304-8608
dc.identifier.uri http://hdl.handle.net/11336/47524
dc.description.abstract HBV phylogenetics and resistance-associated mutations (RAMs) were surveyed by next-generation sequencing of 21 longitudinal samples from seven patients entering antiviral therapy. The virus populations were dominated by a few abundant lineages that coexisted with substantial numbers of low-frequency variants. A few low-frequency RAMs were observed before treatment, but new ones emerged, and their frequencies increased during therapy. Together, these results support the idea that chronic HBV infection is dominated by a few virus lineages and that an accompanying plethora of diverse, low-frequency variants may function as a reservoir that potentially contribute to viral genetic plasticity, potentially affecting patient outcome.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer Wien
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject HBV
dc.subject HIV
dc.subject NGS
dc.subject RAMS
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-05-29T21:12:07Z
dc.identifier.eissn 1432-8798
dc.journal.volume 161
dc.journal.number 10
dc.journal.pagination 2885-2891
dc.journal.pais Austria
dc.journal.ciudad Viena
dc.description.fil Fil: Jones, Leandro Roberto. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Trelew; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Sede, Mariano Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil Fil: Manrique, Julieta Marina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Trelew; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.journal.title Archives of Virology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00705-016-2959-8
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-016-2959-8
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)