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dc.contributor.author
Piloni, Natacha Estefanía  
dc.contributor.author
Puntarulo, Susana Ángela  
dc.date.available
2018-06-06T17:56:38Z  
dc.date.issued
2016-11  
dc.identifier.citation
Piloni, Natacha Estefanía; Puntarulo, Susana Ángela; A Simple Kinetic Model to Estimate Ascorbyl Radical Steady State Concentration in Rat Central Nervous System. Effect of Subchronic Fe Overload; OMICS International; Bioenergetics: Open Access; 5; 2; 11-2016; 1-3; 125  
dc.identifier.issn
2167-7662  
dc.identifier.uri
http://hdl.handle.net/11336/47511  
dc.description.abstract
All biological systems, contain many antioxidants; including water-soluble compounds, such as ascorbic acid. The one-electron oxidation of ascorbate (AH¯produces the ascorbyl radical (A•), that has a relatively long lifetime compared to other species, such as hydroxyl radical, peroxyl, alkoxyl, and carbon-centered lipid free radicals. A• has been proposed as a marker of oxidative stress either in vitro, or in vivo in numerous systems. The application of a simple kinetic analysis allowed us to estimate the steady state concentration of A•. These data were successfully compared to experimental values obtained using Electron Paramagnetic Resonance (EPR) in rat brain under physiological conditions. The model was also applied to estimate the response to stress due to subchronic Fe overload.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
OMICS International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ascorbyl Radical  
dc.subject
Brain  
dc.subject
Kinetic Model  
dc.subject
Iron  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
A Simple Kinetic Model to Estimate Ascorbyl Radical Steady State Concentration in Rat Central Nervous System. Effect of Subchronic Fe Overload  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-05T20:05:17Z  
dc.journal.volume
5  
dc.journal.number
2  
dc.journal.pagination
1-3; 125  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.journal.title
Bioenergetics: Open Access  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4172/2167-7662.1000e125  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/a-simple-kinetic-model-to-estimate-ascorbyl-radical-steady-state-concentration-in-rat-central-nervous-system-effect-of-subchronic-2167-7662-1000e125.php?aid=83544  

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