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dc.contributor.author
Monterrubio, Carles
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Paco, Sonia
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Olaciregui, Nagore G.
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Pascual Pasto, Guillem
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Vila Ubach, Monica
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Cuadrado Vilanova, Maria
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Ferrandiz, M. Mar
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Castillo Ecija, Helena
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Glisoni, Romina Julieta
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Kuplennik, Nataliya
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Jungbluth, Achim
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de Torres, Carmen
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Lavarino, Cinzia
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Cheung, N. K. V.
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Mora, Jaume
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Sosnik, Alejandro Dario
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Montero Carcaboso, Angel
dc.date.available
2018-06-06T15:22:09Z
dc.date.issued
2017-06
dc.identifier.citation
Monterrubio, Carles; Paco, Sonia; Olaciregui, Nagore G.; Pascual Pasto, Guillem; Vila Ubach, Monica; et al.; Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8; Elsevier Science; Journal of Controlled Release; 255; 6-2017; 108-119
dc.identifier.issn
0168-3659
dc.identifier.uri
http://hdl.handle.net/11336/47474
dc.description.abstract
Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated with the anti-GD2 mouse mAb 3F8 at a mean density of seven antibody molecules per NP. The accumulation of drug-loaded NPs targeted with 3F8 versus with control antibody was monitored by microdialysis in patient-derived GD2-expressing neuroblastoma xenografts. We showed that the extent of tumor penetration by SN-38 was significantly higher in mice receiving the targeted nano-drug delivery system when compared to non-targeted system or free drug. This selective penetration of the tumor extracellular fluid translated into a strong anti-tumor effect prolonging survival of mice bearing GD2-high neuroblastomas in vivo.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Gd2-Targeted Nanoparticles
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Intratumor Drug Distribution
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Microdialysis
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Tumor Extracellular Fluid
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Neuroblastoma
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Irinotecan/Sn-38
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Pdx Models
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T13:38:26Z
dc.journal.volume
255
dc.journal.pagination
108-119
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Monterrubio, Carles. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
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Fil: Paco, Sonia. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Olaciregui, Nagore G.. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Pascual Pasto, Guillem. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
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Fil: Vila Ubach, Monica. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Cuadrado Vilanova, Maria. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Ferrandiz, M. Mar. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Castillo Ecija, Helena. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
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Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
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Fil: Kuplennik, Nataliya. Technion-Israel Institute of Technology; Israel
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Fil: Jungbluth, Achim. Memorial Sloan-Kettering Cancer Center; Estados Unidos
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Fil: de Torres, Carmen. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Lavarino, Cinzia. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Cheung, N. K. V.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Mora, Jaume. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.description.fil
Fil: Sosnik, Alejandro Dario. Technion-Israel Institute of Technology; Israel
dc.description.fil
Fil: Montero Carcaboso, Angel. Institut de Recerca Sant Joan de Deu; España. Hospital Sant Joan de Deu Barcelona; España
dc.journal.title
Journal of Controlled Release
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jconrel.2017.04.016
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168365917305357
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/28412222/
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