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dc.contributor.author
Martos Schott, Yanina Victoria
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Braz, Bárbara Yael
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Beccaria, Juan Pablo
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Murer, Mario Gustavo
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Belforte, Juan Emilio
dc.date.available
2018-06-06T14:57:03Z
dc.date.issued
2017-03
dc.identifier.citation
Martos Schott, Yanina Victoria; Braz, Bárbara Yael; Beccaria, Juan Pablo; Murer, Mario Gustavo; Belforte, Juan Emilio; Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons; Society for Neuroscience; Journal of Neuroscience; 37; 11; 3-2017; 2849-2858
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/47462
dc.description.abstract
The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons (SCIN), have been involved in their pathophysiology. To explore the role of SCIN in relation to perseverative behaviors we characterized a new transgenic mouse model in which inducible ablation of SCIN is achieved with high efficiency in a cell-type and region specific manner. Mice were subjected to an extensive behavioral testing including assessment of social behaviors and corticostriatal functional connectivity was evaluated in vivo. Selective SCIN ablation leads to altered social interactions together with exacerbated spontaneously emitted repetitive behaviors. Lesioned mice showed normal motor coordination, balance, and general locomotion. Interestingly, only environmentally-driven, but not self-directed, repetitive behaviors are exacerbated in lesioned mice. Remarkably, in mice with SCIN ablation the normal pattern of social exploration is continuously replayed. The emerging pattern of social interactions is highly predictable and invariant across time. In vivo electrophysiological recordings indicate that SCIN ablation results in an increase of the functional connectivity between different cortical areas and the motor, but not associative, region of the striatum. Our results identify a role of SCIN in suppressing perseverative behaviors including social related ones. In sum, SCIN ablation in mice leads to exacerbated ritualistic-like behaviors that impact on social performance providing a link between SCIN dysfunction and social impairments present in psychiatric disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cholinergic Interneurons
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Corticostriatal Connectivity
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Genetic Ablation
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Mice
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Social Behavior
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Striatum
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-05T20:13:29Z
dc.journal.volume
37
dc.journal.number
11
dc.journal.pagination
2849-2858
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Martos Schott, Yanina Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Braz, Bárbara Yael. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Beccaria, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Murer, Mario Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1523/JNEUROSCI.3460-16.2017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/early/2017/02/13/JNEUROSCI.3460-16.2017
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