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dc.contributor.author
Piloni, Natacha Estefanía
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Reiteri, Romina Macarena
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Hernando, Marcelo Pablo
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Cervino, Claudio O.
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Puntarulo, Susana Ángela
dc.date.available
2018-06-05T21:51:56Z
dc.date.issued
2017-10
dc.identifier.citation
Piloni, Natacha Estefanía; Reiteri, Romina Macarena; Hernando, Marcelo Pablo; Cervino, Claudio O.; Puntarulo, Susana Ángela; Differential Effect of Acute Iron Overload on Oxidative Status and Antioxidant Content in Regions of Rat Brain
; SAGE Publications; Toxicologic Pathology; 45; 8; 10-2017; 1067-1076
dc.identifier.issn
0192-6233
dc.identifier.uri
http://hdl.handle.net/11336/47427
dc.description.abstract
The hypothesis of this study is that the cerebral cortex, hippocampus, and striatum of the rat brain are differentially affected in terms of oxidative stress and antioxidant capacity by acute Fe overload because Fe is distributed in a heterogeneous fashion among different regions and cells of the brain. The effects on the lipophilic and hydrophilic cellular environment were compared between regions and with the whole brain. A single dose of Fe-dextran increased Fe deposits, reaching a maximum after 6 hr. Both in whole brain and in cortex region, the ascorbyl/ascorbate content ratio was increased after 6 hr of Fe administration, while in striatum and hippocampus, there was no significant changes after Fe overload. Total thiol content decreased in whole brain and cortex, while there were no significant changes in striatum and hippocampus after Fe overload. The content of α-tocopherol (α-T), whether measured in the whole brain or in the isolated regions, did not change following Fe treatment. Lipid radical (LR•) generation rate after Fe-dextran overload only increased in the cortex region. The LR•/α-T content ratio was increased by Fe treatment in cortex but not in the whole brain, striatum, or hippocampus, in agreement with the study tested hypothesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antioxidants
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Brain Regions
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Electron Paramagnetic Resonance (Epr)
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Iron
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Oxidative Stress
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Differential Effect of Acute Iron Overload on Oxidative Status and Antioxidant Content in Regions of Rat Brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-05T20:07:21Z
dc.journal.volume
45
dc.journal.number
8
dc.journal.pagination
1067-1076
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Reiteri, Romina Macarena. Universidad de Morón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hernando, Marcelo Pablo. Universidad de Morón; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Cervino, Claudio O.. Universidad de Morón; Argentina
dc.description.fil
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.journal.title
Toxicologic Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0192623317734847
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1177/0192623317734847
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