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dc.contributor.author
Muresan, Ximena Maria
dc.contributor.author
Sticozzi, Claudia
dc.contributor.author
Belmonte, Giuseppe
dc.contributor.author
Savelli, Vinno
dc.contributor.author
Evelson, Pablo Andrés
dc.contributor.author
Valacchi, Giuseppe
dc.date.available
2018-06-05T21:06:27Z
dc.date.issued
2017-11
dc.identifier.citation
Muresan, Ximena Maria; Sticozzi, Claudia; Belmonte, Giuseppe; Savelli, Vinno; Evelson, Pablo Andrés; et al.; Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure; Elsevier Ireland; Mechanisms Of Ageing And Development; 172; 11-2017; 78-85
dc.identifier.issn
0047-6374
dc.identifier.uri
http://hdl.handle.net/11336/47420
dc.description.abstract
Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Our group has demonstrated that SR-B1 levels are down-regulated in human cultured keratinocytes by environmental stressors, such as cigarette smoke, via cellular redox imbalance. Our present study aimed to investigate whether such down-regulation was confirmed in a 3D skin model and under other environmental challengers such as particulate matter and ozone. We also investigated the association between oxidation-induced SR-B1 modulation and impaired wound closure. The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CIGARETTE SMOKE
dc.subject
OXIDATIVE STRESS
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OZONE
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PARTICULATE MATTER
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POLLUTION
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RHE
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SKIN
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WOUND HEALING
dc.subject.classification
Salud Ocupacional
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-05T20:07:02Z
dc.journal.volume
172
dc.journal.pagination
78-85
dc.journal.pais
Irlanda
dc.journal.ciudad
Shannon
dc.description.fil
Fil: Muresan, Ximena Maria. Università di Ferrara; Italia
dc.description.fil
Fil: Sticozzi, Claudia. Università di Ferrara; Italia
dc.description.fil
Fil: Belmonte, Giuseppe. Università di Ferrara; Italia
dc.description.fil
Fil: Savelli, Vinno. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Valacchi, Giuseppe. Università di Ferrara; Italia. North Carolina State University; Estados Unidos
dc.journal.title
Mechanisms Of Ageing And Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0047637417301161
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mad.2017.11.006
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