Artículo
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish
Pisera Fuster, Antonella
; Otero, Sofía
; Talevi, Alan
; Bruno Blanch, Luis Enrique; Bernabeu, Ramon Oscar
Fecha de publicación:
04/2017
Editorial:
Wiley-liss, Div John Wiley & Sons Inc
Revista:
Synapse
ISSN:
0887-4476
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.
Palabras clave:
Animal-Behavior
,
Anticonvulsant-Drugs
,
Seizures
,
Zebrafish
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Citación
Pisera Fuster, Antonella; Otero, Sofía; Talevi, Alan; Bruno Blanch, Luis Enrique; Bernabeu, Ramon Oscar; Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish; Wiley-liss, Div John Wiley & Sons Inc; Synapse; 71; 4; 4-2017; 1-10; e21961
Compartir
Altmétricas