Artículo
Weeds as biocatalysts in the stereoselective synthesis of chiral phenylethanols used as key intermediates for pharmaceuticals
Bordon, Daniela Laura; Villalba, Leonardo D.; Aimar, Mario Leandro; Cantero, Juan Jose; Vázquez, Ana María; Formica, Stella Maris; Krapacher, Claudio Ricardo
; Rossi, Laura Isabel
; Rossi, Laura Isabel
Fecha de publicación:
08/2015
Editorial:
Elsevier
Revista:
Biocatalysis and Agricultural Biotechnology
ISSN:
1878-8181
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
This paper describes the search for novel vegetal biocatalysts for the stereoselective reduction of prochiral phenylketones. In this study, twenty native weeds were tested and Eryngium horridum Malme (Apiaceae) was proven to be an effective biocatalyst for the stereoselective reduction of acetophenone to (S)-1-phenylethanol (96% conversion, >99.9 e.e.%). Using this biocatalyst, fourteen chiral (S)-phenylethanols with excellent enantiomeric excesses (>98%) and variable conversions (30–100%) were obtained.
https://www.sciencedirect.com/science/article/pii/S1878818115000900
http://dx.doi.org/10.1016/j.bcab.2015.08.001
http://dx.doi.org/10.1016/j.bcab.2015.08.001
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Citación:
Bordon, Daniela Laura; Villalba, Leonardo D. ; Aimar, Mario Leandro; Cantero, Juan Jose; Vázquez, Ana María; et al.; Weeds as biocatalysts in the stereoselective synthesis of chiral phenylethanols used as key intermediates for pharmaceuticals; Elsevier; Biocatalysis and Agricultural Biotechnology; 4; 4; 8-2015; 493-499
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Articulos(INFIQC) [915]
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA