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dc.contributor.author
Aparicio, Jose Luis
dc.contributor.author
Ottobre Saborido, Macarena Aylén
dc.contributor.author
Duhalde Vega, Maite
dc.contributor.author
Coutelier, Jean-Paul
dc.contributor.author
Van Snick, Jacques
dc.contributor.author
Retegui, Lilia Alicia
dc.date.available
2018-06-05T18:30:45Z
dc.date.issued
2017-09
dc.identifier.citation
Aparicio, Jose Luis; Ottobre Saborido, Macarena Aylén; Duhalde Vega, Maite; Coutelier, Jean-Paul; Van Snick, Jacques ; et al.; Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection; John Libbey Eurotext Ltd; European Cytokine Network; 28; 3; 9-2017; 111-117
dc.identifier.issn
1148-5493
dc.identifier.uri
http://hdl.handle.net/11336/47349
dc.description.abstract
Mice infected with mouse hepatitis virus A59 (MHV-A59) develop hepatitis and autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH), a fact closely related to the release of alarmins such as uric acid and/or high-mobility group box protein 1 (HMGB1). We studied the effect of neutralizing monoclonal antibodies (MAb) against IL-17A in our model of mouse MHV-A59-infection. MAb anti IL-17F and anti-IFNγ were used to complement the study. Results showed that transaminase levels markedly decreased in MHV-A59-infected mice treated with MAb anti-IL-17A whereas plasmatic Ig concentration sharply increased. Conversely, MAb anti-IL-17F enhanced transaminase liberation and did not affect Ig levels.Serum IFNγ was detected in mice infected with MHV-A59, and its concentration increased after MAb anti-IL-17A administration. Besides, MAb anti-IFNγ greatly augmented transaminase plasmatic levels. IL-17A neutralization did not affect MHV-A59-induction of HMGB1 liberation and slightly augmented plasmatic uric acid concentration. However, mice treated with the MAb failed to produce autoAb to FAH. The above results suggest a reciprocal regulation of Th1 and Th17 cells acting on the different MHV-A59 effects. In addition, it is proposed that IL-17A is involved in alarmins adjuvant effects leading to autoAb expression.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Libbey Eurotext Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Il-17
dc.subject
Ifng
dc.subject
Mhv
dc.subject
Autoab
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-04T17:17:39Z
dc.journal.volume
28
dc.journal.number
3
dc.journal.pagination
111-117
dc.journal.pais
Francia
dc.journal.ciudad
Montrouge
dc.description.fil
Fil: Aparicio, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Ottobre Saborido, Macarena Aylén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Duhalde Vega, Maite. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Coutelier, Jean-Paul. Université Catholique de Louvain; Bélgica
dc.description.fil
Fil: Van Snick, Jacques. Ludwig Institute for Cancer Research; Bélgica
dc.description.fil
Fil: Retegui, Lilia Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
European Cytokine Network
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jle.com/fr/revues/ecn/e-docs/effects_of_interleukin_17a_il_17a_neutralization_on_murine_hepatitis_virus_mhv_a59_infection_310871/article.phtml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1684/ecn.2017.0399
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