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dc.contributor.author
Huang, Y. L.
dc.contributor.author
Supasai, S.
dc.contributor.author
Kucera, H.
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Gaikwad, N. W.
dc.contributor.author
Adamo, Ana María
dc.contributor.author
Mathieu, Patricia Andrea
dc.contributor.author
Oteiza, Patricia Isabel
dc.date.available
2018-06-04T19:56:39Z
dc.date.issued
2016-01
dc.identifier.citation
Huang, Y. L.; Supasai, S.; Kucera, H.; Gaikwad, N. W.; Adamo, Ana María; et al.; Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation; Royal Society of Chemistry; Food & Function; 7; 1; 1-2016; 84-92
dc.identifier.issn
2042-650X
dc.identifier.uri
http://hdl.handle.net/11336/47197
dc.description.abstract
This paper investigated if marginal zinc nutrition during gestation could affect fetal exposure to glucocorticoids as a consequence of a deregulation of placental 11βHSD2 expression. Placenta 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) plays a central role as a barrier protecting the fetus from the deleterious effects of excess maternal glucocorticoids. Rats were fed control (25 μg zinc per g diet) or marginal (10 μg zinc per g diet, MZD) zinc diets from day 0 through day 19 (GD19) of gestation. At GD19, corticosterone concentration in plasma, placenta, and amniotic fluid was similar in both groups. However, protein and mRNA levels of placenta 11βHSD2 were significantly higher (25% and 58%, respectively) in MZD dams than in controls. The main signaling cascades modulating 11βHSD2 expression were assessed. In MZD placentas the activation of ERK1/2 and of the downstream transcription factor Egr-1 was low, while p38 phosphorylation and SP-1-DNA binding were low compared to the controls. These results point to a central role of ERK1/Egr-1 in the regulation of 11βHSD2 expression under the conditions of limited zinc availability. In summary, results show that an increase in placenta 11βHSD2 expression occurs as a consequence of gestational marginal zinc nutrition. This seems to be due to a low tissue zinc-associated deregulation of ERK1/2 rather than to exposure to high maternal glucocorticoid exposure. The deleterious effects on brain development caused by diet-induced marginal zinc deficiency in rats do not seem to be due to fetal exposure to excess glucocorticoids.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Zinc Deficiency
dc.subject
Glucocorticoids
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-04T17:03:18Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
84-92
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Huang, Y. L.. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Supasai, S.. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Kucera, H.. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Gaikwad, N. W.. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Adamo, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
dc.description.fil
Fil: Mathieu, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas ; Argentina
dc.description.fil
Fil: Oteiza, Patricia Isabel. University of California at Davis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Food & Function
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1039/c5fo01203a
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2016/FO/C5FO01203A
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