Development of a Mouse Model of Shiga Toxin 2 (STX2) Intoxication for Testing Therapeutic Agents against Hemolytic Uremic Syndrome (HUS).

Hemolytic Uremic Syndrome (HUS) caused by infections with Shiga toxin (Stx)-producing E. coli is a life-threatening complication characterized by acute renal failure, thrombocytopenia and hemolytic anemia. Stx is the main pathogenic factor. Therefore, the mouse model by intravenous administration of a single lethal dose of Stx is often used to explore its pathogenic mechanisms. The aim of this work was to develop an alternative mouse model of Stx type 2 (Stx2) intoxication to evaluate new therapeutic strategies.

Palabras clave: Shiga Toxine , Hemolytic Uremic Syndrome , Recombinant Proteins , Dose Response Relationship

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/47195

DOI: http://dx.doi.org/10.2174/1381612822666160628080350

URL: http://www.eurekaselect.com/143667/article

Colecciones

Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY

Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL

Citación

Mejias, María Pilar; Fernández Brando, Romina Jimena; Ramos, Maria Victoria; Abrey Recalde, Maria Jimena; Zotta, Elsa; et al.; Development of a Mouse Model of Shiga Toxin 2 (STX2) Intoxication for Testing Therapeutic Agents against Hemolytic Uremic Syndrome (HUS).; Bentham Science Publishers; Current Pharmaceutical Design; 22; 34; 6-2016; 5294-5299

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