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Artículo

Atrial natriuretic peptide reduces inflammation and enhances apoptosis in rat acute pancreatitis

Najenson, Ana ClaraIcon ; Courreges, Ana PaulaIcon ; Perazzo, J. C.; Rubio, Maria FernandaIcon ; Vatta, Marcelo SergioIcon ; Bianciotti, Liliana GracielaIcon
Fecha de publicación: 03/2018
Editorial: Wiley Blackwell Publishing, Inc
Revista: Acta Physiologica
ISSN: 1748-1708
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Aim: We previously reported that atrial natriuretic peptide (ANP) reduces serum amylase and intrapancreatic trypsinogen activation in the onset of acute pancreatitis whereas secretin increases them. In the present work, we sought to establish the effect of ANP and secretin on the inflammatory response and cell death in experimental acute pancreatitis. Methods: The expression and activity of key inflammatory mediators and apoptosis were evaluated in the presence or absence of the atrial peptide, secretin or both in cerulein‐induced acute pancreatitis in rats. Also, ultrastructural changes in pancreatic acinar cells were assessed by transmission electron microscopy. Results: ANP significantly reduced NF‐κB activation and TNF‐α intrapancreatic levels. Furthermore, it decreased inducible nitric oxide synthase and cyclooxygenase 2 expression and activity while it diminished myeloperoxidase activity. ANP also stimulated apoptosis as shown by caspase‐3 expression and activation as well as TUNEL assay. These findings correlated well with the ultrastructural changes observed in the exocrine pancreas. Although secretin reduced various inflammatory markers, it also diminished caspase‐3 activation and the overall response was the aggravation of the disease as reflected by the ultrastructural alterations of pancreatic acinar cells. In the presence of ANP, various effects evoked by secretin were antagonized. Conclusion: Present findings show that ANP significantly attenuated the severity of acute pancreatitis in the rat by inducing apoptosis and reducing the inflammatory response and further suggest that ANP may have eventual therapeutic implications in the disease and/or in medical interventions at risk of its developing like endoscopic retrograde cholangiopancreatography.
Palabras clave: Cell Death , Inflammation , Natriuretic Peptides , Pancreatitis
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47165
DOI: http://dx.doi.org/10.1111/apha.12992
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.12992
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Articulos(IDIM) [485]
Articulos de INST.DE INVEST.MEDICAS
Citación
Najenson, Ana Clara; Courreges, Ana Paula; Perazzo, J. C.; Rubio, Maria Fernanda; Vatta, Marcelo Sergio; et al.; Atrial natriuretic peptide reduces inflammation and enhances apoptosis in rat acute pancreatitis; Wiley Blackwell Publishing, Inc; Acta Physiologica; 222; 3; 3-2018; 1-12; e12992
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