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dc.contributor.author
Farrelly, Lorna  
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Rosato Siri, María Victoria  
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Föcking, Melanie  
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Codagnone, Martín Gabriel  
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Reines, Analia Gabriela  
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Dicker, Patrick  
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Wynne, Kieran  
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Farrell, Michael  
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Cannon, Mary  
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Cagney, Gerard  
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Pasquini, Juana Maria  
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Cotter, David R.  
dc.date.available
2018-06-04T14:59:18Z  
dc.date.issued
2017-09  
dc.identifier.citation
Farrelly, Lorna; Rosato Siri, María Victoria; Föcking, Melanie; Codagnone, Martín Gabriel; Reines, Analia Gabriela; et al.; The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis; Wiley VCH Verlag; Proteomics (weinheim. Print); 17; 17-18; 9-2017; 1-24  
dc.identifier.issn
1615-9853  
dc.identifier.uri
http://hdl.handle.net/11336/47119  
dc.description.abstract
Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, the precise molecular mechanisms are still unknown. Here, we utilized high throughput mass spectrometry to examine the proteomic effects of pID in adulthood on the rat frontal cortex area (FCA). In addition, the FCA proteome was examined in adulthood following risperidone treatment in adolescence to see if these effects could be prevented. We identified 1501 proteins of which 100 were significantly differentially expressed in the FCA at post-natal day 90. Pathway Analysis of proteins affected by pID revealed changes in metabolic processes, including the tricyclic acid cycle, mitochondrial dysfunction, and P13K/Akt signaling. Interestingly, most of these protein changes were not present in the adult pID offspring who received risperidone in adolescence. Considering the link between prenatal iron deficiency and several neurodevelopmental disorders such as autism and schizophrenia these presented results bring new perspectives to understand the role of iron in metabolic pathways and provide novel biomarkers for future studies of prenatal iron deficiency.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley VCH Verlag  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Schizophrenia  
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Myelination  
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Antipsychotics  
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Proteomics  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-01T19:21:48Z  
dc.journal.volume
17  
dc.journal.number
17-18  
dc.journal.pagination
1-24  
dc.journal.pais
Alemania  
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Weinheim  
dc.description.fil
Fil: Farrelly, Lorna. Beaumont Hospital; Irlanda  
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Fil: Rosato Siri, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina  
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Fil: Föcking, Melanie. Beaumont Hospital; Irlanda  
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Fil: Codagnone, Martín Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina  
dc.description.fil
Fil: Reines, Analia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina  
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Fil: Dicker, Patrick. College of Surgeons in Ireland; Irlanda  
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Fil: Wynne, Kieran. University College Dublin; Irlanda  
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Fil: Farrell, Michael. Beaumont Hospital; Irlanda  
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Fil: Cannon, Mary. Beaumont Hospital; Irlanda  
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Fil: Cagney, Gerard. University College Dublin; Irlanda  
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Fil: Pasquini, Juana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina  
dc.description.fil
Fil: Cotter, David R.. Beaumont Hospital; Irlanda  
dc.journal.title
Proteomics (weinheim. Print)  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/pmic.201600407  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/pmic.201600407