Mostrar el registro sencillo del ítem
dc.contributor.author
Paixão, L.
dc.contributor.author
Velez, Leandro Martin
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Santos, B. R.
dc.contributor.author
Tusset, C.
dc.contributor.author
Lecke, S. B.
dc.contributor.author
Motta, Alicia Beatriz
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Spritzer, Poli Mara
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2018-06-01T21:11:10Z
dc.date.issued
2016-06
dc.identifier.citation
Paixão, L.; Velez, Leandro Martin; Santos, B. R.; Tusset, C.; Lecke, S. B.; et al.; Early ovarian follicular development in prepubertal Wistar rats acutely exposed to androgens; Cambridge University Press; Journal of Developmental Origins of Health and Disease; 7; 4; 6-2016; 384-390
dc.identifier.issn
2040-1752
dc.identifier.uri
http://hdl.handle.net/11336/47081
dc.description.abstract
Androgens may directly modulate early ovarian follicular development in preantral stages and androgen excess before puberty may disrupt this physiological process. Therefore, the aim of this study was to investigate the dynamics of follicular morphology and circulating androgen and estradiol levels in prepubertal Wistar rats acutely exposed to androgens. Prepubertal female Wistar rats were distributed into three groups: control, equine chorionic gonadotropin (eCG) intervention and eCG plus dehydroepiandrosterone (DHEA) intervention (eCG+DHEA). Serum DHEA, testosterone and estradiol levels were determined, and ovarian morphology and morphometry were assessed. The eCG+DHEA group presented increased serum estradiol and testosterone levels as compared with the control group (P<0.01), and higher serum DHEA concentration v. the eCG-only and control groups (P<0.01). In addition, the eCG+DHEA group had a higher number of, and larger-sized, primary and secondary follicles as compared with the control group (P<0.05). The eCG group presented intermediate values for number and size of primary and secondary follicles, without significant differences as compared with the other two groups. The number of antral follicles was higher in the eCG+DHEA and eCG groups v. controls (P<0.05). The number of primordial, atretic and cystic follicles were similar in all groups. In conclusion, the present experimental model using an acute eCG+DHEA intervention was useful to investigate events involved in initial follicular development under hyperandrogenic conditions, and could provide a reliable tool to study defective follicular development with possible deleterious reproductive consequences later in life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sindrome de Ovario Poliquistico
dc.subject
Hiperandrogenismo
dc.subject
Desarrollo Folicular
dc.subject
Atresia Folicular
dc.subject.classification
Inmunología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Early ovarian follicular development in prepubertal Wistar rats acutely exposed to androgens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-01T19:26:29Z
dc.journal.volume
7
dc.journal.number
4
dc.journal.pagination
384-390
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Paixão, L.. Hospital de Clínicas de Porto Alegre; Brasil
dc.description.fil
Fil: Velez, Leandro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Santos, B. R.. Hospital de Clínicas de Porto Alegre; Brasil
dc.description.fil
Fil: Tusset, C.. Hospital de Clínicas de Porto Alegre; Brasil
dc.description.fil
Fil: Lecke, S. B.. Hospital de Clínicas de Porto Alegre; Brasil
dc.description.fil
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Spritzer, Poli Mara. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title
Journal of Developmental Origins of Health and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1017/S2040174416000222
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/early-ovarian-follicular-development-in-prepubertal-wistar-rats-acutely-exposed-to-androgens/AF7D7C809A6CCF536BD5DF9A70DE1BFF
Archivos asociados