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dc.contributor.author Bistoletti, Mariana
dc.contributor.author Alvarez, Luis Ignacio
dc.contributor.author Lanusse, Carlos Edmundo
dc.contributor.author Moreno Torrejon, Laura
dc.date.available 2016-03-09T17:54:10Z
dc.date.issued 2013-03
dc.identifier.citation Bistoletti, Mariana; Alvarez, Luis Ignacio; Lanusse, Carlos Edmundo; Moreno Torrejon, Laura; Disposition kinetics of albendazole and metabolites in laying hens; Wiley; Journal of Veterinary Pharmacology and Therapeutics; 36; 2; 3-2013; 161-168
dc.identifier.issn 0140-7783
dc.identifier.uri http://hdl.handle.net/11336/4703
dc.description.abstract An increasing prevalence of roundworm parasites in poultry, particularly in litter-based housing systems, has been reported. However, few anthelmintic drugs are commercially available for use in avian production systems. The anthelmintic efficacy of albendazole (ABZ) in poultry has been demonstrated well. The goal of this work was to characterize the ABZ and metabolites plasma disposition kinetics after treatment with different administration routes in laying hens. Twenty-four laying hens Plymouth Rock Barrada were distributed into three groups and treated with ABZ as follows: intravenously at 10 mg⁄ kg (ABZ i.v.); orally at the same dose (ABZ oral); and in medicated feed at 10 mgÆkg ⁄ day for 7 days (ABZ feed). Blood samples were taken up to 48 h posttreatment (ABZ i.v. and ABZ oral) and up to 10 days poststart feed medication (ABZ feed). The collected plasma samples were analyzed using high-performance liquid chromatography. ABZ and its albenda-zole sulphoxide (ABZSO) and ABZSO2 metabolites were recovered in plasma after ABZ i.v. administration.ABZ parent compound showed an initial concentration of 16.4 ± 2.0 lg ⁄ mL, being rapidly metabolized into the ABZSO and ABZSO2 metabolites. The ABZSO maximum concentration (Cmax) (3.10 ± 0.78 lg ⁄ mL)was higher than that of ABZSO2 Cmax (0.34 ± 0.05 lg ⁄ mL). The area under the concentration vs time curve (AUC) for ABZSO (21.9 ± 3.6 lgÆh⁄ mL) was higher than that observed for ABZSO2 and ABZ (7.80 ± 1.02 and 12.0 ± 1.6 lgÆh⁄ mL, respectively). The ABZ body clearance (Cl) was 0.88 ± 0.11 LÆh⁄ kg with an elimination half-life (T1 ⁄ 2el) of 3.47 ± 0.73 h. The T1 ⁄ 2el for ABZSO and ABZSO2 were 6.36 ± 1.50 and 5.40 ± 1.90 h, respectively. After ABZ oral administration, low ABZ plasma concentrations were measured between 0.5 and 3 h posttreatment. ABZ was rapidly metabolized to ABZSO (Cmax, 1.71 ± 0.62 lg ⁄ mL) and ABZSO2 (Cmax, 0.43 ± 0.04 lg ⁄ mL). The metabolite systemic exposure (AUC) values were 18.6 ± 2.0 and 10.6 ± 0.9 lgÆh⁄ mL for ABZSO and ABZSO2, respectively. The half-life values after ABZ oral were similar (5.91 ± 0.60 and 5.57 ± 1.19 h for ABZSO and ABZSO2, respectively) to those obtained after ABZ i.v. administration. ABZ was not recovered from the bloodstream after ABZ feed administration. AUC values of ABZSO and ABZSO2 were 61.9 and 92.4 lgÆh⁄ mL, respectively. The work reported here provides useful information on the pharmacokinetic behavior of ABZ after both i.v. and oral administrations in hens, which is a useful first step to evaluate its potential as an anthelmintic tool for use in poultry.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ALBENDAZOLE
dc.subject LAYING HENS
dc.subject DISPOSITION KINETICS
dc.subject.classification Ciencias Veterinarias
dc.subject.classification Ciencias Veterinarias
dc.subject.classification CIENCIAS AGRÍCOLAS
dc.title Disposition kinetics of albendazole and metabolites in laying hens
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-03-30 10:35:44.97925-03
dc.journal.volume 36
dc.journal.number 2
dc.journal.pagination 161-168
dc.journal.pais Estados Unidos
dc.journal.ciudad Hoboken
dc.description.fil Fil: Bistoletti, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title Journal of Veterinary Pharmacology and Therapeutics
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2012.01401.x/abstract;jsessionid=138631F301195CB74D1F216BC138BB57.f03t02
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2012.01401.x
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/issn/0140-7783


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)