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Artículo

Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production

Wolfson, Manuel LuisIcon ; Muzzio, Damián Oscar; Ehrhardt, Jens; Franchi, Ana MariaIcon ; Zygmunt, Marek; Jensen, Cristian FedericoIcon
Fecha de publicación: 08/2016
Editorial: Elsevier Ireland
Revista: Journal of Reproductive Immunology
ISSN: 0165-0378
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

The endocannabinoid system consists in a family of lipids that binds to and activates cannabinoid receptors. There are two receptors so far described, the cannabinoid receptor 1 (CB1) and 2 (CB2). In the context of pregnancy, the endocannabinoid system was shown participates in different key aspects of reproductive events. B-lymphocytes are pleiotropic cells belonging to the adaptive arm of the immune system. Besides immunoglobulin production, B-lymphocytes were recently shown to be actively involved in antigen presentation as well as cytokine production, thus playing a central role in immunity. In this study we first aimed to characterize the expression of CB1 and CB2 receptors in B cells during pregnancy and then analyze the impact of their activation in term of cytokine production by B cells from pregnant and non-pregnant mice. We observed that the expression of CB1 and CB2 receptors in B-lymphocytes is differentially regulated during pregnancy. While CB2 expression is down regulated CB1 is augmented in B-lymphocytes of pregnant mice. Additionally, the treatment of activated B-lymphocytes with specific CB1 and CB2 agonists, showed a different response in term of cytokine production. Particularly, CB1 against boosted the production of the anti-inflammatory cytokine IL-10 by activated B-lymphocytes from pregnant mice.
Palabras clave: Cannabinoid Receptor , B Cell , Cytokine , Pregnancy
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47025
DOI: https://dx.doi.org/10.1016/j.jri.2016.05.001
URL: https://www.sciencedirect.com/science/article/pii/S0165037816300262
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Wolfson, Manuel Luis; Muzzio, Damián Oscar; Ehrhardt, Jens; Franchi, Ana Maria; Zygmunt, Marek; et al.; Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production; Elsevier Ireland; Journal of Reproductive Immunology; 116; 8-2016; 23-27
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