The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
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Citación:Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; et al.; Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs; Hindawi Publishing Corporation; Biomed Research International; 2013; 7-2013; 920305-920305