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dc.contributor.author
Wilkens, Mirja
dc.contributor.author
Cohrs, Imke
dc.contributor.author
Lifschitz, Adrian Luis
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dc.contributor.author
Fraser, David R.
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Olszewski, Katharina
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Schoeder, Bernd
dc.contributor.author
Breves, Gerhard
dc.date.available
2016-03-08T18:50:22Z
dc.date.issued
2013-07
dc.identifier.citation
Wilkens, Mirja; Cohrs, Imke; Lifschitz, Adrian Luis; Fraser, David R.; Olszewski, Katharina; et al.; Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 136; 7-2013; 44-46
dc.identifier.issn
0960-0760
dc.identifier.uri
http://hdl.handle.net/11336/4687
dc.description.abstract
It has recently been demonstrated that prepartum administered 25-hydroxyvitamin D3 (25-OHD3) is a promising candidate to assist the maintenance of peripartal calcium homeostasis in dairy cows. Since the incidence of peripartal hypocalcemia and the reported beneficial effects of the treatment are both associated with the lactation number, we investigated pharmacokinetic aspects of 25-OHD3 related to the age of dairy cows. The daily oral administration of 3mg 25-OHD3 in rapeseed oil as well as a treatment with 4 and 6mg included in the feed during the last eight to ten days of gestation resulted in linear dosage- and age-dependent increases in plasma 25-OHD3. After parturition the administration was stopped and blood samples were taken to calculate the plasma half-life. Irrespective of the supplemented dosage, cows starting the 2nd lactation showed a significantly longer plasma half-life of 25-OHD3 than cows starting the 3rd or higher lactation. Age-dependent differences in the increase of plasma 25-OHD3 could already be found before parturition when calcium homeostasis was not yet significantly challenged. Additionally, no correlations between plasma half-life of 25-OHD3 and 1,25-dihydroxyvitamin D3, PTH or the bone resorption marker CrossLaps were observed after parturition. Thus we conclude that the influence of the lactation number on the pharmacokinetics of 25-OHD3 is related directly to the age of the cows. This article is part of a Special Issue entitled ´Vitamin D Workshop´.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
25-Hydroxyvitamin D
dc.subject
Metabolism
dc.subject
Cattle
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
136
dc.journal.pagination
44-46
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Wilkens, Mirja. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
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Fil: Cohrs, Imke. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
dc.description.fil
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
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Fil: Fraser, David R.. University of Sydney. Faculty of Veterinary Science; Australia
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Fil: Olszewski, Katharina. DSM Nutritional Products; Suiza
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Fil: Schoeder, Bernd. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
dc.description.fil
Fil: Breves, Gerhard. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
dc.journal.title
Journal of Steroid Biochemistry and Molecular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076012002464
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jsbmb.2012.11.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/0960-0760
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