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dc.contributor.author
Rómoli, Santiago  
dc.contributor.author
Amicarelli, Adriana Natacha  
dc.contributor.author
Ortiz, Oscar Alberto  
dc.contributor.author
Scaglia, Gustavo Juan Eduardo  
dc.contributor.author
Di Sciascio, Fernando Agustín  
dc.date.available
2018-05-31T14:51:14Z  
dc.date.issued
2016-10  
dc.identifier.citation
Rómoli, Santiago; Amicarelli, Adriana Natacha; Ortiz, Oscar Alberto; Scaglia, Gustavo Juan Eduardo; Di Sciascio, Fernando Agustín; Nonlinear control of the dissolved oxygen concentration integrated with a biomass estimator for production of Bacillus thuringiensis δ-endotoxins; Pergamon-Elsevier Science Ltd; Computers and Chemical Engineering; 93; 10-2016; 13-24  
dc.identifier.issn
0098-1354  
dc.identifier.uri
http://hdl.handle.net/11336/46788  
dc.description.abstract
Bacillus thuringiensis is a microorganism that allows the biosynthesis of -endotoxins with toxic prop-erties against some insect larvae, being often used for the production of biological insecticides. A keyissue for the bioprocess design consists in adequately tracking a pre-specified optimal profile of the dis-solved oxygen concentration. To this effect, this paper aims at developing a novel control law based on anonlinear dynamic inversion method. The closed-loop strategy includes an observer based on a BayesianRegression with Gaussian Process, which is used for on-line estimating the biomass present in the biore-actor. Unlike other approaches, the proposed controller leads to an improved response time with effectivedisturbance rejection properties, while simultaneously prevents undesired oscillations of the dissolvedoxygen concentration. Simulation results based on available experimental data were used to show theeffectiveness of the proposal.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Δ-Endotoxins Production Dissolved Oxygen Control  
dc.subject
Nonlinear Dynamic Inversion  
dc.subject
Batch Bioprocess  
dc.subject
Bacillus Thuringiensis  
dc.subject.classification
Ingeniería de Sistemas y Comunicaciones  
dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Nonlinear control of the dissolved oxygen concentration integrated with a biomass estimator for production of Bacillus thuringiensis δ-endotoxins  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-05-30T14:30:16Z  
dc.journal.volume
93  
dc.journal.pagination
13-24  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Rómoli, Santiago. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina  
dc.description.fil
Fil: Amicarelli, Adriana Natacha. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; Argentina  
dc.description.fil
Fil: Ortiz, Oscar Alberto. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina  
dc.description.fil
Fil: Scaglia, Gustavo Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina  
dc.description.fil
Fil: Di Sciascio, Fernando Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; Argentina  
dc.journal.title
Computers and Chemical Engineering  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.compchemeng.2016.05.017  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0098135416301752