Artículo

Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones

Faccone, Diego FranciscoIcon ; Lopez Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; Gagetti, Paula Silvana; Ceriana, Paola; Corso, Alejandra
Fecha de publicación: 10/2016
Editorial: Elsevier Science
Revista: Infection, Genetics and Evolution
ISSN: 1567-1348
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We report an H. parainfluenzae clinical isolate resistant to cefotaxime and with decreased susceptibility to ciprofloxacinrecovered from a patient with cystic fibrosis. The isolate had elevated MICs of ampicillin (256 mg/L), amoxicillin-clavulanate(8 mg/L), cefuroxime (8 mg/L) and cefotaxime (4 mg/L), and showed a β-lactamase-producing amoxicillin-clavulanicacid-resistant (BLPACR) phenotype. A blaTEM-1 plus five amino acid substitutions in the PBP3 were found:Ser385Thr, Val511Ala, Ile519Val, Asn526Lys and Asp551Leu. MIC of ciprofloxacin was 0.5 mg/L, and substitutions ingyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.
Palabras clave: Haemophilus , Cefotaxime , Fluoroquinolone , Pbp3
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/46787
DOI: https://dx.doi.org/10.1016/j.meegid.2016.08.003
URL: https://www.sciencedirect.com/science/article/pii/S1567134816303409
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Citación
Faccone, Diego Francisco; Lopez Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; et al.; Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones; Elsevier Science; Infection, Genetics and Evolution; 44; 10-2016; 507-509
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