Artículo
Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
Altube, María Julia
; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José
; Romero, Eder Lilia
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
08/2016
Editorial:
Future Medicine
Revista:
Nanomedicine
ISSN:
1743-5889
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared. Materials & methods: The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100–150 nm DP-containing ApH (dioleylphosphatidylethanolamine: Halorubrum tebenquichense total polar archaeolipids:cholesteryl hemisuccinate 4.2:2.8:3 w:w) was tested on different cell lines. Size and HPTS retention of ApH and conventional LpH (dioleylphosphatidylethanolamine:cholesteryl hemisuccinate 7:3 w:w) before and after nebulization were determined. Results & conclusion: DP-ApH suppressed IL-6 and TNF-α on phagocytic cells. Nebulized after 6-month storage, LpH increased size and completely lost its HPTS while ApH3 conserved size and polydispersity, fully retaining its original HPTS content.
Palabras clave:
Lung
,
Nebulization
,
Subcellular Delivery
,
Macrophages Targeting
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Altube, María Julia; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José; et al.; Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes; Future Medicine; Nanomedicine; 11; 16; 8-2016; 2103-2117
Compartir
Altmétricas