Artículo
Chemodivergent fungal oxidation of isochroman
Fecha de publicación:
12/2016
Editorial:
Elsevier Science
Revista:
Journal of Molecular Catalysis B: Enzymatic
ISSN:
1381-1177
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This work extends the present knowledge about the ability of filamentous fungi and Baker’s Yeast to selectively transform oxygen-containing compounds. Previously, it has been demonstrated that several species of the Aspergillus genus are able to perform selective oxidation of benzopyrans. Isochroman or 3,4-dihydro-1H-benzopyran (1) was chosen as model substrate for the biotransformation since related motifs are often found in the structure of natural products with important biological and pharmacological activities. All the tested strains showed the ability to oxidize 1. Chemodivergent reaction pathways between the employed microorganisms were observed. The use of cytochrome P450 enzyme inhibitors, and different oxygenation conditions allowed to inquire about the type of enzymes involved in the process. The results obtained were compared with chemical one-electron oxidation of compound 1 and thus, a metabolic pathway was proposed.
Palabras clave:
Biotransformation
,
Chemodivergent Synthesis
,
Isochroman
,
Whole Fungal Cells
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Identificadores
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Furque, Gabriela Inés; Bisogno, Fabricio Román; Sosa, Virginia Estela; Chemodivergent fungal oxidation of isochroman
; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 134; Part B; 12-2016; 310-316
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