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dc.contributor.author
Cabalén, María Eugenia
dc.contributor.author
Cabral, Maria Fernanda
dc.contributor.author
Sanmarco, Liliana Maria
dc.contributor.author
Andrada, Marta Cecilia
dc.contributor.author
Onofrio, Luisina Inés
dc.contributor.author
Ponce, Nicolás Eric
dc.contributor.author
Aoki, Maria del Pilar
dc.contributor.author
Gea, Susana
dc.contributor.author
Cano, Roxana Carolina
dc.date.available
2018-05-29T19:04:04Z
dc.date.issued
2016-02
dc.identifier.citation
Cabalén, María Eugenia; Cabral, Maria Fernanda; Sanmarco, Liliana Maria; Andrada, Marta Cecilia; Onofrio, Luisina Inés; et al.; Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model; Oncotarget eiditorial; Oncotarget; 7; 12; 2-2016; 13400-13415
dc.identifier.issn
1949-2553
dc.identifier.uri
http://hdl.handle.net/11336/46484
dc.description.abstract
Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been entirely explored. A novel diet-induced obesity model (DIO) was developed in C57BL/6 wild type mice to examine the effect of chronic infection (DIO+I) on metabolic parameters and on obesity-related disorders. Dyslipidemia, hyperleptinemia, and cardiac/hepatic steatosis were strongly developed in DIO mice. Strikingly, although these metabolic alterations were collectively improved by infection, plasmatic apoB100 levels remain significantly increased in DIO+I, suggesting the presence of pro-atherogenic small and dense LDL particles. Moreover, acute insulin resistance followed by chronic hyperglycemia with hypoinsulinemia was found, evidencing an infection-related-diabetes progression. These lipid and glucose metabolic changes seemed to be highly dependent on TLR4 expression since TLR4-/- mice were protected from obesity and its complications. Notably, chronic infection promoted a strong increase in MCP-1 producing macrophages with a M2 (F4/80+CD11c-CD206+) phenotype associated to oxidative stress in visceral adipose tissue of DIO+I mice. Importantly, infection reduced lipid content but intensified inflammatory infiltrates in target tissues. Thus, parasite persistence in an obesogenic environment and the resulting host immunometabolic dysregulation may contribute to diabetes/atherosclerosis progression.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oncotarget eiditorial
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Obesity
dc.subject
Inmunometabolism
dc.subject
Adipose Tissue Macrophages
dc.subject
Innate Immunity
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-22T21:48:42Z
dc.journal.volume
7
dc.journal.number
12
dc.journal.pagination
13400-13415
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Cabalén, María Eugenia. Universidad Católica de Córdoba; Argentina
dc.description.fil
Fil: Cabral, Maria Fernanda. Universidad Católica de Córdoba; Argentina
dc.description.fil
Fil: Sanmarco, Liliana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Andrada, Marta Cecilia. Universidad Católica de Córdoba; Argentina
dc.description.fil
Fil: Onofrio, Luisina Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Ponce, Nicolás Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Aoki, Maria del Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Gea, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Cano, Roxana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Oncotarget
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26921251
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.18632/oncotarget.7630


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