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dc.contributor.author
Nagymihály, Marianna
dc.contributor.author
Veluchamy, Alaguraj
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Györgypál, Zoltán
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Ariel, Federico Damian
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Jégu, Teddy
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Benhamed, Moussa
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Szücs, Attila
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Kereszt, Attila
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Mergaert, Peter
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Kondorosi, Éva
dc.date.available
2018-05-29T16:17:54Z
dc.date.issued
2017-04
dc.identifier.citation
Nagymihály, Marianna; Veluchamy, Alaguraj; Györgypál, Zoltán; Ariel, Federico Damian; Jégu, Teddy; et al.; Ploidy-dependent changes in the epigenome of symbiotic cells correlate with specific patterns of gene expression; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 114; 17; 4-2017; 4543-4548
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/46428
dc.description.abstract
The formation of symbiotic nodule cells in Medicago truncatula is driven by successive endoreduplication cycles and transcriptional reprogramming in different temporal waves including the activation of more than 600 cysteine-rich NCR genes expressed only in nodules. We show here that the transcriptional waves correlate with growing ploidy levels and have investigated how the epigenome changes during endoreduplication cycles. Differential DNA methylation was found in only a small subset of symbiotic nodulespecific genes, including more than half of the NCR genes, whereas in most genes DNA methylation was unaffected by the ploidy levels and was independent of the genes´ active or repressed state. On the other hand, expression of nodule-specific genes correlated with ploidy-dependent opening of the chromatin as well as, in a subset of tested genes, with reduced H3K27me3 levels combined with enhanced H3K9ac levels. Our results suggest that endoreduplicationdependent epigenetic changes contribute to transcriptional reprogramming in the differentiation of symbiotic cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chromatin Structure
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Dna Methylation
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Medicago Truncatula
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Nodule-Specific Cysteine-Rich Peptides
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Symbiosis
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Ploidy-dependent changes in the epigenome of symbiotic cells correlate with specific patterns of gene expression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-11T21:17:09Z
dc.journal.volume
114
dc.journal.number
17
dc.journal.pagination
4543-4548
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Nagymihály, Marianna. Université Paris Sud; Francia. Hungarian Academy of Sciences; Hungría
dc.description.fil
Fil: Veluchamy, Alaguraj. King Abdullah University of Science and Technology; Arabia Saudita
dc.description.fil
Fil: Györgypál, Zoltán. Hungarian Academy of Sciences; Hungría
dc.description.fil
Fil: Ariel, Federico Damian. Instituto de Agrobiotecnología del Litoral (conicet-unl); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Jégu, Teddy. Université Paris Sud; Francia
dc.description.fil
Fil: Benhamed, Moussa. Université Paris Sud; Francia
dc.description.fil
Fil: Szücs, Attila. Hungarian Academy of Sciences; Hungría
dc.description.fil
Fil: Kereszt, Attila. Biological Research Center At Hungarian Academy Of Sciences;
dc.description.fil
Fil: Mergaert, Peter. Université Paris Sud; Francia
dc.description.fil
Fil: Kondorosi, Éva. Université Paris Sud; Francia. Hungarian Academy of Sciences; Hungría
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.1704211114
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