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dc.contributor.author
Orlow, Irene
dc.contributor.author
Tommasi, Diana V.
dc.contributor.author
Bloom, Bradley
dc.contributor.author
Ostrovnaya, Irina
dc.contributor.author
Cotignola, Javier Hernan
dc.contributor.author
Mujumdar, Urvi
dc.contributor.author
Busam, Klaus J.
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Jungbluth, Achim A.
dc.contributor.author
Scolyer, Richard A.
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Thompson, John F.
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Armstrong, Bruce K.
dc.contributor.author
Berwick, Marianne
dc.contributor.author
Thomas, Nancy E.
dc.contributor.author
Begg, Colin B.
dc.date.available
2018-05-28T14:25:48Z
dc.date.issued
2009-08
dc.identifier.citation
Orlow, Irene; Tommasi, Diana V.; Bloom, Bradley; Ostrovnaya, Irina; Cotignola, Javier Hernan; et al.; Evaluation of the clonal origin of multiple primary melanomas using molecular profiling; Nature Publishing Group; Journal Of Investigative Dermatology; 129; 8; 8-2009; 1972-1982
dc.identifier.issn
0022-202X
dc.identifier.uri
http://hdl.handle.net/11336/46221
dc.description.abstract
Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases. © 2009 The Society for Investigative Dermatology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melanoma
dc.subject
Microsatellite
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Molecular Profiling
dc.subject
Clonal Origin
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T17:54:07Z
dc.journal.volume
129
dc.journal.number
8
dc.journal.pagination
1972-1982
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Orlow, Irene. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Tommasi, Diana V.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Bloom, Bradley. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Ostrovnaya, Irina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Mujumdar, Urvi. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Busam, Klaus J.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.description.fil
Fil: Jungbluth, Achim A.. Ludwig Institute for Cancer Research; Estados Unidos
dc.description.fil
Fil: Scolyer, Richard A.. Royal Prince Alfred Hospital; Australia
dc.description.fil
Fil: Thompson, John F.. Royal Prince Alfred Hospital; Australia
dc.description.fil
Fil: Armstrong, Bruce K.. University of Sydney and Cancer Council New South Wale; Australia
dc.description.fil
Fil: Berwick, Marianne. University of New Mexico; Estados Unidos
dc.description.fil
Fil: Thomas, Nancy E.. University of North Carolina; Estados Unidos
dc.description.fil
Fil: Begg, Colin B.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
dc.journal.title
Journal Of Investigative Dermatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/jid.2009.4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022202X15344584
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