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dc.contributor.author
Nicola, Juan Pablo
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dc.contributor.author
Carrasco, Nancy
dc.contributor.author
Masini Repiso, Ana María
dc.date.available
2018-05-24T14:30:56Z
dc.date.issued
2015-03
dc.identifier.citation
Nicola, Juan Pablo; Carrasco, Nancy; Masini Repiso, Ana María; Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine; Elsevier Academic Press Inc; Vitamins and Hormones Series; 98; 3-2015; 1-31
dc.identifier.issn
0083-6729
dc.identifier.uri
http://hdl.handle.net/11336/46052
dc.description.abstract
Thyroid hormones are critical for the normal development, growth, and functional maturation of several tissues, including the central nervous system. Iodine is an essential constituent of the thyroid hormones, the only iodine-containing molecules in vertebrates. Dietary iodide (I(-)) absorption in the gastrointestinal tract is the first step in I(-) metabolism, as the diet is the only source of I(-) for land-dwelling vertebrates. The Na(+)/I(-) symporter (NIS), an integral plasma membrane glycoprotein located in the brush border of enterocytes, constitutes a central component of the I(-) absorption system in the small intestine. In this chapter, we review the most recent research on structure/function relations in NIS and the protein's I(-) transport mechanism and stoichiometry, with a special focus on the tissue distribution and hormonal regulation of NIS, as well as the role of NIS in mediating I(-) homeostasis. We further discuss recent findings concerning the autoregulatory effect of I(-) on I(-) metabolism in enterocytes: high intracellular I(-) concentrations in enterocytes decrease NIS-mediated uptake of I(-) through a complex array of posttranscriptional mechanisms, e.g., downregulation of NIS expression at the plasma membrane, increased NIS protein degradation, and reduction of NIS mRNA stability leading to decreased NIS mRNA levels. Since the molecular identification of NIS, great progress has been made not only in understanding the role of NIS in I(-) homeostasis but also in developing protocols for NIS-mediated imaging and treatment of various diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Academic Press Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dietary Iodide
dc.subject
Sodium/Iodide Symporter
dc.subject
Thyroid Hormones
dc.subject
Small Intestine Absorptive Enterocytes
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-22T21:48:00Z
dc.journal.volume
98
dc.journal.pagination
1-31
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Burlington
dc.description.fil
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Carrasco, Nancy. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Masini Repiso, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Vitamins and Hormones Series
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0083672914000156
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/bs.vh.2014.12.002
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