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dc.contributor.author
Castro Castro, Antonio
dc.contributor.author
Marchesin, Valentina
dc.contributor.author
Monteiro, Pedro
dc.contributor.author
Lodillinsky, Catalina
dc.contributor.author
Rossé, Carine
dc.contributor.author
Chavrier, Philippe
dc.date.available
2018-05-24T12:03:16Z
dc.date.issued
2016-10
dc.identifier.citation
Castro Castro, Antonio; Marchesin, Valentina; Monteiro, Pedro; Lodillinsky, Catalina; Rossé, Carine; et al.; Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion; Annual Reviews; Annual Review Of Cell And Developmental Biology; 32; 1; 10-2016; 555-576
dc.identifier.issn
1081-0706
dc.identifier.uri
http://hdl.handle.net/11336/46037
dc.description.abstract
Metastasis is responsible for most of cancer-associated deaths. Accumulating evidence based on 3D migration models has revealed a diversity of invasive migratory schemes reflecting the plasticity of tumor cells to switch between proteolytic and nonproteolytic modes of invasion. Yet, initial stages of localized regional tumor dissemination require proteolytic remodeling of the extracellular matrix to overcome tissue barriers. Recent data indicate that surface-exposed membrane type 1?matrix metalloproteinase (MT1-MMP), belonging to a group of membrane-anchored MMPs, plays a central role in pericellular matrix degradation during basement membrane and interstitial tissue transmigration programs. In addition, a large body of work indicates that MT1-MMP is targeted to specialized actin-rich cell protrusions termed invadopodia, which are responsible for matrix degradation. This review describes the multistep assembly of actin-based invadopodia in molecular details. Mechanisms underlying MT1-MMP traffic to invadopodia through endocytosis/recycling cycles, which are key to the invasive program of carcinoma cells, are discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Annual Reviews
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cancer Cell Invasion
dc.subject
Mt1-Mmp
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Invadopodia
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-20T14:33:21Z
dc.journal.volume
32
dc.journal.number
1
dc.journal.pagination
555-576
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Palo Alto, California
dc.description.fil
Fil: Castro Castro, Antonio. Instituto Pasteur; Francia
dc.description.fil
Fil: Marchesin, Valentina. Imagine Institute of Genetic Diseases; Francia
dc.description.fil
Fil: Monteiro, Pedro. University of London; Reino Unido
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Fil: Lodillinsky, Catalina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rossé, Carine. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Chavrier, Philippe. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
dc.journal.title
Annual Review Of Cell And Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1146/annurev-cellbio-111315-125227
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/10.1146/annurev-cellbio-111315-125227
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