Artículo
Cytochrome c, a hub linking energy, redox, stress and signalling pathways in mitochondria and other cell compartments
Fecha de publicación:
04/2016
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Physiologia Plantarum
ISSN:
0031-9317
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cytochrome c (CYTc) is a soluble redox-active heme protein that transfers electrons from Complex III to Complex IV in the cyanide-sensitive mitochondrial respiratory pathway. CYTc biogenesis is a complex process that requires multiple steps until the mature active protein is obtained. CYTc levels and activity are finely regulated, revealing the importance of this protein not only as electron carrier but also in many other processes. In this review, we describe the role of CYTc in mitochondrial respiration, from its canonical role as electron carrier for ATP production to its involvement in protein import and the stabilization of respiratory complexes and supercomplexes. In plants, CYTc is connected to the synthesis of the antioxidant ascorbate and the detoxification of toxic compounds. Finally, CYTc is also a multi-functional signalling molecule that influences the balance between life and death, acting in energy provision for cellular functions or triggering programmed cell death. The confluence of several metabolic routes into a single protein that links redox reactions with energy producing pathways seems logical from the point of view of cellular economy, control and organization.
Palabras clave:
Cytochrome C
,
Mitochondria
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Articulos(IAL)
Articulos de INSTITUTO DE AGROBIOTECNOLOGIA DEL LITORAL
Articulos de INSTITUTO DE AGROBIOTECNOLOGIA DEL LITORAL
Citación
Welchen, Elina; Gonzalez, Daniel Hector; Cytochrome c, a hub linking energy, redox, stress and signalling pathways in mitochondria and other cell compartments; Wiley Blackwell Publishing, Inc; Physiologia Plantarum; 157; 3; 4-2016; 310-321
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