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dc.contributor.author
Ferrari, Carina Cintia
dc.contributor.author
Johnson, Brett A.
dc.contributor.author
Leon, Michael
dc.contributor.author
Pixley, Sarah K.
dc.date.available
2018-05-16T15:52:23Z
dc.date.issued
2003-01
dc.identifier.citation
Ferrari, Carina Cintia; Johnson, Brett A.; Leon, Michael; Pixley, Sarah K.; Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb.; Springer/Plenum Publishers; Neurochemical Research; 28; 1; 1-2003; 29-43
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/45351
dc.description.abstract
Insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) are involved in growth of neurons. In the rat olfactory epithelium, we previously showed IGF-IR immunostaining in subsets of olfactory receptor neurons. We now report that IGF-IR staining was heaviest in the olfactory nerve layer of the rat olfactory bulb at embryonic days 18, and 19 and postnatal day 1, with labeling of protoglomeruli. In the adult, only a few glomeruli were IGF-IR-positive, some of which were unusually small and strongly labeled. Some IGF-IR-positive fibers penetrated deeper into the external plexiform layer, even in adults. In developing tissues, IGF-IR staining co-localized with that for olfactory marker protein and growth associated protein GAP-43, but to a lesser extent with synaptophysin. In the adult, IGF-IR-positive fibers were compartmentalized within glomeruli. IGF-I may play a role in glomerular synaptogenesis and/or plasticity, possibly contributing to development of coding patterns for odor detection or identification.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Olfactory Bulb
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Igf-1r
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Olfactory Majker Protein
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Synaptophysin
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-10T15:45:54Z
dc.identifier.eissn
1573-6903
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
29-43
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Ferrari, Carina Cintia. University Of Cincinnati; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Johnson, Brett A.. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Leon, Michael. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Pixley, Sarah K.. University of Cincinnati; Estados Unidos
dc.journal.title
Neurochemical Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1021639926941
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1023/A:1021639926941
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