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dc.contributor.author Panero, Julieta
dc.contributor.author Alves Paiva, Raquel
dc.contributor.author Roisman, Alejandro
dc.contributor.author Santana Lemos, Barbara
dc.contributor.author Falcao, Roberto P.
dc.contributor.author Oliveira, Gustavo
dc.contributor.author Martins, Diego
dc.contributor.author Stanganelli, Carmen Graciela
dc.contributor.author Slavutsky, Irma Rosa
dc.contributor.author Calado, Rodrigo
dc.date.available 2018-05-16T02:23:19Z
dc.date.issued 2016-02
dc.identifier.citation Panero, Julieta; Alves Paiva, Raquel; Roisman, Alejandro; Santana Lemos, Barbara; Falcao, Roberto P.; et al.; Acquired TERT promoter mutations activate TERT expression in mantle cell lymphoma; John Willey & Sons; American Journal Of Hematology; 91; 5; 2-2016; 481-485
dc.identifier.issn 0361-8609
dc.identifier.uri http://hdl.handle.net/11336/45317
dc.description.abstract Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm with poor prognosis. Acquired telomerasereverse transcriptase gene promoter (TERTp) mutations are among the most frequent somatic non-codingmutations in cancers. In this study, the prevalence of TERTp mutations in 24 MCL and 21 other lymphoidneoplasias (oLN) was investigated. Eight MCL samples (33%) carried TERTp mutations, two homozygous andsix heterozygous (seven C228T and one C250T), which directly correlated with higher TERT transcription,mitochondrial DNA copy number, and IGHV mutational status in MCL neoplastic cells. TERTp mutations werenot found in oLN. TERTp mutations correlated with more lymphoma proliferation and tumor burden, assuggested by the higher number of lymphoma cells circulating in peripheral blood, and tended to associatewith longer MCL telomeres, especially in homozygous mutants, although not statistically significant.Telomere-biology genes were overexpressed in MCL cells in comparison to healthy lymphocytes, but werenot influenced by mutation status. The findings described for the first time that acquired TERTp mutationsare common in MCL but not in other lymphoid neoplasms. It was also demonstrated that TERTp mutationsassociated with higher TERT mRNA expression in MCL cells in vivo and higher tumor burden, suggestingthese mutations as a driver event in MCL development and progression.
dc.format application/pdf
dc.language.iso eng
dc.publisher John Willey & Sons
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject HTERT
dc.subject MANTLE CELL LYMPHOMA
dc.subject SHELTERIN
dc.subject DNA
dc.subject LEUKEMIA
dc.subject LIMPHOMA
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Acquired TERT promoter mutations activate TERT expression in mantle cell lymphoma
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-05-03T14:00:10Z
dc.identifier.eissn 1096-8652
dc.journal.volume 91
dc.journal.number 5
dc.journal.pagination 481-485
dc.journal.pais Estados Unidos
dc.journal.ciudad Nueva York
dc.description.fil Fil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Alves Paiva, Raquel. Universidade de Sao Paulo; Brasil. Fundação de Amparo À Pesquisa do Estado de São Paulo; Brasil
dc.description.fil Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Santana Lemos, Barbara. Universidade de Sao Paulo; Brasil. Fundação de Amparo À Pesquisa do Estado de São Paulo; Brasil
dc.description.fil Fil: Falcao, Roberto P.. Universidade de Sao Paulo; Brasil. Fundação de Amparo À Pesquisa do Estado de São Paulo; Brasil
dc.description.fil Fil: Oliveira, Gustavo. Universidade de Sao Paulo; Brasil
dc.description.fil Fil: Martins, Diego. Universidade de Sao Paulo; Brasil
dc.description.fil Fil: Stanganelli, Carmen Graciela. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Slavutsky, Irma Rosa. Imex, Conicet-academia Nacional de Medicina; Argentina
dc.description.fil Fil: Calado, Rodrigo. Fundação de Amparo À Pesquisa do Estado de São Paulo; Brasil. Universidade de Sao Paulo; Brasil
dc.journal.title American Journal Of Hematology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.24324
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ajh.24324
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/26852175
dc.conicet.fuente unificacion


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)