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dc.contributor.author
Hibberd, Patricia L.
dc.contributor.author
Hansen, Nellie I.
dc.contributor.author
Wang, Marie E.
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Goudar, Shivaprasad S.
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Pasha, Omrana
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Esamai, Fabian
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Chomba, Elwyn
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Garces, Ana
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Althabe, Fernando
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Derman, Richard J.
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Goldenberg, Robert L.
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Liechty, Edward A.
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Carlo, Waldemar A.
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Hambidge, K. Michael
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Krebs, Nancy F.
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Buekens, Pierre
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McClure, Elizabeth M.
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Koso Thomas, Marion
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Patel, Archana B.
dc.date.available
2018-05-15T19:24:35Z
dc.date.issued
2016-05
dc.identifier.citation
Hibberd, Patricia L.; Hansen, Nellie I.; Wang, Marie E.; Goudar, Shivaprasad S.; Pasha, Omrana; et al.; Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study; BioMed Central; Reproductive Health Matters (print); 65; 5-2016; 1-13
dc.identifier.issn
1742-4755
dc.identifier.uri
http://hdl.handle.net/11336/45253
dc.description.abstract
BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possible, it is important to know how and where to target these regimens, but data on the incidence and outcomes of pSBI are limited. METHODS: We used data prospectively collected at 7 rural community-based sites in 6 low and middle income countries participating in the NICHD Global Network's Maternal and Newborn Health Registry, between January 1, 2010 and December 31, 2013. Participants included pregnant women and their live born neonates followed for 6 weeks after delivery and assessed for maternal and infant outcomes. RESULTS: In a cohort of 248,539 infants born alive between 2010 and 2013, 32,088 (13 %) neonates met symptomatic criteria for pSBI. The incidence of pSBI during the first 6 weeks of life varied 10 fold from 3 % (Zambia) to 36 % (Pakistan), and overall case fatality rates varied 8 fold from 5 % (Kenya) to 42 % (Zambia). Significant variations in incidence of pSBI during the study period, with proportions decreasing in 3 sites (Argentina, Kenya and Nagpur, India), remaining stable in 3 sites (Zambia, Guatemala, Belgaum, India) and increasing in 1 site (Pakistan), cannot be explained solely by changing rates of facility deliveries. Case fatality rates did not vary over time. CONCLUSIONS: In a prospective population based registry with trained data collectors, there were wide variations in the incidence and case fatality of pSBI in rural communities and in trends over time. Regardless of these variations, the burden of pSBI is still high and strategies to implement timely diagnosis and treatment are still urgently needed to reduce neonatal mortality.
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application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Neonatal Sepsis
dc.subject
Rural Communities
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Low Middle Income Countries
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Possible Severe Bacterial Infections
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Incidence of Neonatal Sepsis
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Case Fatality Rates from Neonatal Sepsis
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Global Health
dc.subject.classification
Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-11T20:39:07Z
dc.journal.number
65
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Hibberd, Patricia L.. Massachusetts General Hospital for Children; Estados Unidos
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Fil: Hansen, Nellie I.. Research Triangle Park. RTI International; Estados Unidos
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Fil: Wang, Marie E.. Massachusetts General Hospital for Children; Estados Unidos
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Fil: Goudar, Shivaprasad S.. Jawaharlal Nehru Medical College; India
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Fil: Pasha, Omrana. Aga Khan University; Pakistán
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Fil: Esamai, Fabian. Moi University; Kenia
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Fil: Chomba, Elwyn. University of Zambia; Zambia
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Fil: Garces, Ana. Instituto de Nutrición de Centro América y Panamá; Guatemala
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Fil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Derman, Richard J.. Christiana Health Care; Estados Unidos
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Fil: Goldenberg, Robert L.. Columbia University; Estados Unidos
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Fil: Liechty, Edward A.. Indiana University; Estados Unidos
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Fil: Carlo, Waldemar A.. University of Alabama at Birmingahm; Estados Unidos
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Fil: Hambidge, K. Michael. University of Colorado. Health Sciences Center; Argentina
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Fil: Krebs, Nancy F.. University of Colorado. Health Sciences Center; Argentina
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Fil: Buekens, Pierre. University of Tulane; Estados Unidos
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Fil: McClure, Elizabeth M.. Research Triangle Park. RTI International; Estados Unidos
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Fil: Koso Thomas, Marion. Eunice Kennedy Shriver National Institute of Child Health and Human Development; Estados Unidos
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Fil: Patel, Archana B.. Lata Medical Research Foundation; India
dc.journal.title
Reproductive Health Matters (print)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12978-016-0177-1
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info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877736/
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info:eu-repo/semantics/altIdentifier/url/https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-016-0177-1
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