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Artículo

Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+ IFNγ- CD4+ T cell expansion through an IL-23 and TGF-β-dependent mechanism in patients with MDR-TB tuberculosis

Basile, Juan IgnacioIcon ; Kviatcovsky, DeniseIcon ; Romero, María MercedesIcon ; Balboa, LucianaIcon ; Monteserin, JohanaIcon ; Ritacco, Gloria VivianaIcon ; López, Beatriz; Sabio y García, Carmen AlejandraIcon ; García, A.; Vescovo, M.; Gonzalez Montaner, Pablo; Palmero, Domingo; Sasiain, María del CarmenIcon ; de la Barrera, Silvia SusanaIcon
Fecha de publicación: 09/2016
Editorial: Wiley Blackwell Publishing, Inc
Revista: Clinical and Experimental Immunology
ISSN: 0009-9104
e-ISSN: 1365-2249
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas; Enfermedades Infecciosas

Resumen

We have previously reported that T cells from patients with multidrug-resistant tuberculosis (MDR-TB) express high levels of IL-17 in response to the MDR strain M(Haarlem family) of Mycobacterium tuberculosis (M.tuberculosis). Herein, we explore the pathways involved in the induction of h17 cells in MDR-TB patients and healthy tuberculin reactors (PPD+HD) by the M strain and the laboratory strain H37Rv. Our results show that IL-1β and IL-6 are crucial for the H37Rv and M-induced expansion of IL-17+IFNγ¯ and IL-17+IFNγ+ in CD4+ T cells from MDR-TB and PPD+HD. IL-23 plays an ambiguous role in Th1 and Th17 profiles: alone, IL-23 is responsible for M.tuberculosis induced IL-17 and IFNγ expression in CD4+ T cells from PPD+HD whereas, together with TGF-β, it promotes IL-17+IFNγ¯ expansion in MDR-TB. In fact, spontaneous and M.tuberculosis-induced TGF-β secretion is increased in cells from MDR-TB being theM strain the highest inducer. Interestingly, TLR-2 signaling mediates the expansion of IL-17+IFNγ¯ cells and the enhancement of latency-associated protein (LAP) expression in CD14+ and CD4+ T cells from MDR-TB, which suggests that M strain promotes IL-17+IFNγ¯ T cells through a strong TLR-2-dependent TGF-β production by antigenpresenting cells and CD4+ T cells. Finally, CD4+ T cells from MDR-TB patients infected with MDR Haarlem strains show higher IL-17+IFNγ¯ and lower IL-17+IFNγ+ levels than LAM-infected patients. The present findings deepen our understanding on the role of IL-17 in MDR-TB and highlight the influence of the genetic background of the infecting M.tuberculosis strain on the ex vivo Th17 response.
Palabras clave: Mycobacterium , Tuberculosis , Mdr , Th17 Response , Mycobacterium
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/45030
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/cei.12873
DOI: http://dx.doi.org/10.1111/cei.12873
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Basile, Juan Ignacio; Kviatcovsky, Denise; Romero, María Mercedes; Balboa, Luciana; Monteserin, Johana; et al.; Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+ IFNγ- CD4+ T cell expansion through an IL-23 and TGF-β-dependent mechanism in patients with MDR-TB tuberculosis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 187; 1; 9-2016; 160-173
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