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Artículo

B cells inhibit the antitumor immunity against an established murine fibrosarcoma

Maglioco, Andrea FlorenciaIcon ; Machuca, Damián GabrielIcon ; Badano, Maria NoelIcon ; Nannini, Paula RominaIcon ; Camerano, Gabriela VeronicaIcon ; Costa, Hector LuisIcon ; Meiss, Roberto; Ruggiero, Raul AlejandroIcon ; Giordano, Mirta NildaIcon ; Dran, Graciela IsabelIcon
Fecha de publicación: 03/2017
Editorial: Spandidos Publications
Revista: 1792-1074
ISSN: 1792-1074
e-ISSN: 1792-1082
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Despite the classic role of B cells in favoring the immune response, an inhibitory action of B lymphocytes in tumor immunity has emerged in certain studies. In methylcolanthrene-induced murine fibrosarcoma (MCC), the loss of immunogenicity and the establishment of tolerance are paralleled by systemic immune suppression and the appearance of B+IL‑10+ cells in tumor‑draining lymph nodes. The present study aimed to assess the role of the B+IL‑10+ cell population in the immune evasion and tolerance induced by MCC through the depletion of B cells in mice at various times of tumor progression: Prior to or subsequent to tumor implantation. Tumor growth and immunological parameters were evaluated. B cell depletion prior to tumor inoculum enhanced tumor growth, initiating the onset of the tumor‑induced systemic immune response; however, an increase in the T regulatory cells (Tregs) at the tumor‑draining lymph node could account for tumor exacerbation. B cell depletion once the tumor was established resulted in decreased tumor growth and a delayed onset of tolerance. Additionally, B cell absence exacerbated T cell dependent‑tumor rejection, reduced Tregs and increased cytotoxic CD8+ T cells. In vitro analysis showed a direct effect of B cells upon T cell proliferation. In conclusion, B cell depletion exerts opposite effects when performed prior to or subsequent to tumor implantation. In this initially immunogenic tumor, B cell absence would delay the establishment of immunological tolerance probably by unmasking a pre‑existing antitumor response. The present findings elucidate the convenience of modulating B cells in the development of future and more effective immunotherapies against cancer.
Palabras clave: B Cells , Tolerance , Regulatory Cells , Tumor Escape
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/45023
URL: https://www.spandidos-publications.com/10.3892/ol.2017.5810
DOI: http://dx.doi.org/ 10.3892/ol.2017.5810
URL: http://dx.doi.org/ 28521429
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431264/
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Articulos(IMEX) [606]
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Maglioco, Andrea Florencia; Machuca, Damián Gabriel; Badano, Maria Noel; Nannini, Paula Romina; Camerano, Gabriela Veronica; et al.; B cells inhibit the antitumor immunity against an established murine fibrosarcoma; Spandidos Publications; 1792-1074; 13; 5; 3-2017; 3225-3232
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