Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"

In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells.

Palabras clave: Cathepsin L , Cysteine Endopeptidases , Gene Expression Regulation , Lymphoid Tissue , T-Lymphocytes

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/45015

DOI: http://dx.doi.org/10.4049/jimmunol.176.9.5135

URL: http://www.jimmunol.org/content/176/9/5135

Colecciones

Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)

Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Lombardi, María Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula MercedeS; Costa, Hector Luis; et al.; Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"; American Association of Immunologists; Journal of Immunology; 176; 9; 12-2006; 5135-5136

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