First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate

Abstract

A first generation dendrimer was evaluated as solubility enhancer of the antitumor compound methyl (5- [propylthio]-1H-benzimidazol-2-yl) carbamate. The den- drimer possess carboxylic acid as terminal groups, which provide high water solubility and a low cytotoxic character. The drug-dendrimer association significantly increases active compound solubility in water, avoiding aggregation.The formulation is stable several weeks in a wide temperature range. The formation of Langmuir monolayers in air?water interface of dendrimer-active compound blends evinces the viability of the complex to generate films for surface-mediated drug delivery systems.