Artículo
Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
Padula, Paula Julieta
; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; Miguel, S. D. L.; Russi, J.; Riquelme, J. Mora; Colucci, N.; Almirón, M.; Rabinovich, Roberto Daniel
Fecha de publicación:
08/2000
Editorial:
American Society for Microbiology
Revista:
Journal of Clinical Microbiology
ISSN:
0095-1137
e-ISSN:
1098-660X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.
Palabras clave:
Hantavirus
,
Genetic Diversity
,
South America
,
Serology
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Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Padula, Paula Julieta; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; et al.; Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America; American Society for Microbiology; Journal of Clinical Microbiology; 38; 8; 8-2000; 3029-3035
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