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dc.contributor.author
Castillo, Victor Alejandro
dc.contributor.author
Giacomini, Damiana Paula
dc.contributor.author
Páez Pereda, Marcelo
dc.contributor.author
Stalla, Johanna
dc.contributor.author
Labeur, Marta
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Theodoropoulou, Marily
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Holsboer, Florian
dc.contributor.author
Grossman, Ashley B.
dc.contributor.author
Stalla, Günter K.
dc.contributor.author
Arzt, Eduardo Simon
dc.date.available
2018-05-09T18:00:49Z
dc.date.issued
2006-09
dc.identifier.citation
Castillo, Victor Alejandro; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Stalla, Johanna; Labeur, Marta; et al.; Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs; Endocrine Society; Endocrinology; 147; 9; 9-2006; 4438-4444
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/44644
dc.description.abstract
Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH and alpha-MSH, the cortisol/creatinine urine ratio, and pituitary magnetic resonance imaging were assessed and compared at different time points. We recorded a significant reduction in plasma ACTH and alpha-MSH, and also in the cortisol/creatinine urine ratio, of the dogs treated with retinoic acid. Pituitary adenoma size was also significantly reduced at the end of retinoic acid treatment. Survival time and all the clinical signs evaluated showed an improvement in the retinoic-acid-treated dogs. No adverse events or signs of hepatotoxicity were observed, suggesting that the drug is not only effective but also safe. Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype. This study highlights the possibility of using retinoic acid as a novel therapy in the treatment of ACTH-secreting tumors in humans with Cushing's disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
.Retinoic Acid
dc.subject
Cushing'S Disease
dc.title
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-06T13:41:44Z
dc.identifier.eissn
1945-7170
dc.journal.volume
147
dc.journal.number
9
dc.journal.pagination
4438-4444
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Stalla, Johanna. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Theodoropoulou, Marily. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Holsboer, Florian. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Grossman, Ashley B.. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/147/9/4438/2528350
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1210/en.2006-0414
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