Artículo

Iridoids As Allelochemicals and DNA Polymerase Inhibitors ⊥

Pungitore, Carlos RodolfoIcon ; Juri Ayub, MaximilianoIcon ; García, MatíasIcon ; Borkowski, Eduardo JorgeIcon ; Sosa, Marta E.; Ciuffo, Gladys MariaIcon ; Giordano, Oscar SantiagoIcon ; Tonn, Carlos EugenioIcon
Fecha de publicación: 03/2004
Editorial: American Chemical Society
Revista: Journal of Natural Products
ISSN: 0163-3864
e-ISSN: 1520-6025
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/44577
URL: https://pubs.acs.org/doi/abs/10.1021/np030238b
DOI: http://dx.doi.org/10.1021/np030238b
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Pungitore, Carlos Rodolfo; Juri Ayub, Maximiliano; García, Matías; Borkowski, Eduardo Jorge; Sosa, Marta E.; et al.; Iridoids As Allelochemicals and DNA Polymerase Inhibitors ⊥; American Chemical Society; Journal of Natural Products; 67; 3; 3-2004; 357-361
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